mHealth, such as apps running on consumer smart devices is becoming increasingly popular and has the potential to profoundly affect healthcare and health outcomes. However, it may be disruptive and results achieved are not always reaching the goals. Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline using the best evidence-based approach to care pathways suited to real-life using mobile technology in allergic rhinitis (AR) and asthma multimorbidity. Patients largely use over-the-counter medications dispensed in pharmacies. Shared decision making centered around the patient and based on self-management should be the norm. Mobile Airways Sentinel networK (MASK), the Phase 3 ARIA initiative, is based on the freely available MASK app (the Allergy Diary, Android and iOS platforms). MASK is available in 16 languages and deployed in 23 countries. The present paper provides an overview of the methods used in MASK and the key results obtained to date. These include a novel phenotypic characterization of the patients, confirmation of the impact of allergic rhinitis on work productivity and treatment patterns in real life. Most patients appear to self-medicate, are often non-adherent and do not follow guidelines. Moreover, the Allergy Diary is able to distinguish between AR medications. The potential usefulness of MASK will be further explored by POLLAR (Impact of Air Pollution on Asthma and Rhinitis), a new Horizon 2020 project using the Allergy Diary.

Academic Medical Center University of Amsterdam Amsterdam The Netherlands

Allergology Department Centre de l'Asthme et des Allergies Hôpital d'Enfants Armand Trousseau Paris France

Allergy and Respiratory Research Group Usher Institute of Population Health Sciences and Informatics University of Edinburgh Medical School Edinburgh UK

Allergy Center CUF Descobertas Hospital Lisbon Portugal

Allergy Department 2nd Pediatric Clinic Athens General Children's Hospital P and A Kyriakou University of Athens 11527 Athens Greece

Allergy Section Department of Internal Medicine Hospital Vall 'dHebron and ARADyAL Research Network Barcelona Spain

Allergy Service University Hospital of Federal University of Santa Catarina Florianópolis Brazil

Allergy Unit Department of Dermatology University Hospital of Zurich Zürich Switzerland

AQuAS Barcelona Spain

Association of Finnish Pharmacists Helsinki Finland

Asthma Reference Center Escola Superior de Ciencias da Santa Casa de Misericordia de Vitoria Vitória Esperito Santo Brazil

Center for Health Technology and Services Research CINTESIS Faculdade de Medicina Universidade do Porto Porto Portugal

Center for Pediatrics and Child Health Institute of Human Development Royal Manchester Children's Hospital University of Manchester Manchester UK

Center for Rhinology and Allergology Wiesbaden Germany

Center of Excellence in Asthma and Allergy Hospital Médica Sur México City Mexico

Centre for Clinical Research Sörmland Uppsala University Eskilstuna Sweden

Centre of Medical Informatics Usher Institute of Population Health Sciences and Informatics The University of Edinburgh Edinburgh UK

CHU de Grenoble Grenoble France

CIBER Epidemiología y Salud Pública Barcelona Spain

CIRFF Federico 2 University Naples Italy

Ciutad Mexico Mexico

Clinic of Children's Diseases and Institute of Health Sciences Department of Public Health Vilnius University Institute of Clinical Medicine Vilnius Lithuania

Clinic of Children's Diseases Faculty of Medicine Vilnius University Vilnius Lithuania

Clinical and Experimental Respiratory Immunoallergy IDIBAPS CIBERES University of Barcelona Barcelona Spain

Comprehensive Allergy Centre Charité Department of Dermatology and Allergy Charité Universitätsmedizin Berlin Berlin Germany

Conseil Général de l'Economie Ministère de l'Economie de l'Industrie et du Numérique Paris France

Consortium of Pharmacies and Services COSAFER Salerno Italy

CRI Clinical Research International Ltd Hamburg Germany

Department of Allergy Immunology and Respiratory Medicine Alfred Hospital and Central Clinical School Monash University Melbourne VIC Australia

Department of Clinical Science and Education Karolinska Institutet Södersjukhuset Stockholm Sweden

Department of Dermatology and Allergy Centre Odense University Hospital Odense Research Center for Anaphylaxis Odense Denmark

Department of ENT Medical University of Graz Graz Austria

Department of Immunology Monash University Melbourne VIC Australia

Department of Internal Medicine Medical University of Graz Graz Austria

Department of Lung Diseases and Clinical Immunology University of Turku Turku Finland

Department of Medical Sciences Allergy and Clinical Immunology Unit University of Torino and Mauriziano Hospital Torino Italy

Department of Medicine Clinical Immunology and Allergy McMaster University Hamilton ON Canada

Department of Medicine Surgery and Dentistry Scuola Medica Salernitana University of Salerno Salerno Italy

Department of Otorhinolaryngology Academic Medical Centre Amsterdam The Netherlands

Department of Otorhinolaryngology Chiba University Hospital Chiba Japan

Department of Otorhinolaryngology Head and Neck Surgery Universitätsmedizin Mannheim Medical Faculty Mannheim Heidelberg University Mannheim Germany

Department of Otorhinolaryngology Univ Hospitals Leuven Louvain Belgium

Department of Otorhinolaryngology University of Crete School of Medicine Heraklion Greece

Department of Prevention of Environmental Hazards and Allergology Medical University of Warsaw Warsaw Poland

Department of Public Health and Primary Care Leiden University Medical Center Leiden The Netherlands

Department of Pulmonary Diseases Cerrahpasa Faculty of Medicine Istanbul University Istanbul Turkey

Department of Pulmonary Diseases Faculty of Medicine Celal Bayar University Manisa Turkey

Department of Respiratory Diseases Montpellier University Hospital Montpellier France

Director of Center of Allergy Immunology and Respiratory Diseases Santa Fe Argentina Center for Allergy and Immunology Santa Fe Argentina

Division for Health Innovation Campania Region and Federico 2 University Hospital Naples Naples Italy

Division of Allergy Immunology University of South Florida Tampa USA

Division of Internal Medicine Asthma and Allergy Barlicki University Hospital Medical University of Lodz Lodz Poland

EFA European Federation of Allergy and Airways Diseases Patients' Associations Brussels Belgium

Epidemiology of Allergic and Respiratory Diseases Department Institute Pierre Louis of Epidemiology and Public Health INSERM UPMC Sorbonne Université Medical School Saint Antoine Paris France

Euforea Brussels Belgium

EUREGHA European Regional and Local Health Association Brussels Belgium

European Academy of Paediatrics Brussels Belgium

Faculty of Health Sciences and CICS UBI Health Sciences Research Centre University of Beira Interior Covilhã Portugal

Faculty of Medicine Transylvania University Brasov Romania

Faculty of Medicine Vilnius University Vilnius Lithuania

GARD Executive Committee Manisa Turkey

Global Allergy and Asthma European Network Berlin Germany

IMIM Barcelona Spain

Imunoalergologia Centro Hospitalar Universitário de Coimbra and Faculty of Medicine University of Coimbra Coimbra Portugal

INSERM U 1168 VIMA Ageing and Chronic Diseases Epidemiological and Public Health Approaches Villejuif Université Versailles St Quentin en Yvelines UMR S 1168 Montigny le Bretonneux France

Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden

Institute of Medical Statistics and Computational Biology Medical Faculty University of Cologne Cologne Germany

iQ4U Consultants Ltd London UK

ISGlobAL Centre for Research in Environmental Epidemiology Barcelona Spain

Johns Hopkins School of Medicine Baltimore MD USA

KYomed INNOV Montpellier France

La Rochelle France

Laboratoire HP2 Grenoble INSERM U1042 Université Grenoble Alpes Grenoble France

MACVIA France Fondation Partenariale FMC VIA LR CHRU Arnaud de Villeneuve 371 Avenue du Doyen Gaston Giraud Montpellier France

Medida Lda Porto Portugal

MedScript Ltd Dundalk Co Louth Ireland

Mexico City Mexico

Nova Southeastern University Fort Lauderdale Florida USA

Peercode BV Geldermalsen The Netherlands

ProAR Nucleo de Excelencia em Asma Federal University of Bahia Vitória da Conquista Brazil

Puebla Puebla Mexico

Reims France

Rhinology Unit and Smell Clinic ENT Department Hospital Clínic University of Barcelona Barcelona Spain

Sachs' Children and Youth Hospital Södersjukhuset Stockholm Sweden

Section of Allergy and Immunology Saint Louis University School of Medicine Saint Louis MO USA

Servicio de Alergia e Immunologia Clinica Santa Isabel Buenos Aires Argentina

Skin and Allergy Hospital Helsinki University Hospital Helsinki Finland

SOS Allergology and Clinical Immunology USL Toscana Centro Prato Italy

Terveystalo Allergy Clinic Turku Finland

UCIBIO REQUINTE Faculty of Pharmacy and Competence Center on Active and Healthy Ageing University of Porto Porto Portugal

Unit of Geriatric Immunoallergology University of Bari Medical School Bari Italy

Universidad Católica de Córdoba Córdoba Argentina

Universitat Pompeu Fabra Barcelona Spain

University Hospital Olomouc Olomouc Czech Republic

UPMC Univ Paris 06 UMR_S 1136 Institut Pierre Louis d'Epidémiologie et de Santé Publique Sorbonne Universités Equipe EPAR 75013 Paris France

Upper Airways Research Laboratory ENT Department Ghent University Hospital Ghent Belgium

UPRES EA220 Pôle des Maladies des Voies Respiratoires Hôpital Foch Université Paris Saclay Suresnes France

WHO GARD Planning Group Salvador Brazil

Woodbrook Medical Centre Loughborough UK

Woolcock Institute of Medical Research University of Sydney and Sydney Local Health District Glebe NSW Australia

Erratum v

Clin Transl Allergy. 2019 Oct 9;9:51. doi: 10.1186/s13601-019-0290-7. PubMed

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