The fat mass and obesity related gene polymorphism influences the risk of rejection in heart transplant patients
Jazyk angličtina Země Dánsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
30408245
DOI
10.1111/ctr.13443
Knihovny.cz E-zdroje
- Klíčová slova
- fat mass and obesity related gene, heart transplantation, rejection, single nucleotide polymorphism,
- MeSH
- gen pro FTO genetika MeSH
- genotyp MeSH
- jednonukleotidový polymorfismus * MeSH
- lidé středního věku MeSH
- lidé MeSH
- následné studie MeSH
- pooperační komplikace diagnóza etiologie genetika MeSH
- přežívání štěpu MeSH
- prognóza MeSH
- rejekce štěpu diagnóza etiologie genetika MeSH
- rizikové faktory MeSH
- transplantace srdce škodlivé účinky MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- FTO protein, human MeSH Prohlížeč
- gen pro FTO MeSH
Heart transplantation is a relatively common treatment for end-stage heart failure. The major complication of heart transplantation is organ rejection. Epigenetic could play a role in the pathogenesis of organ rejection, and the FTO gene is a mediator of DNA methylation. We analyzed a tagging FTO SNP rs17817449 in both donor and recipient DNA obtained through 370 heart transplantations. Recipient FTO genotypes were not associated with either type of rejection or with the general increase in the risk of rejection. When compared with patients without a history of rejection, carriers of transplanted hearts with the FTO TT genotype exhibited a significantly increased risk (P = 0.02) of suffering from both types of rejection in comparison to carriers of hearts with at least one G allele (OR; 95% CI = 2.56; 1.15-5.69). Our results suggest that the donor, but not the recipient, FTO genotype could be a significant predictor of acute rejection in heart transplant patients.
Cardio Centre Institute for Clinical and Experimental Medicine Prague Czech Republic
Statistic Unit Institute for Clinical and Experimental Medicine Prague Czech Republic
Citace poskytuje Crossref.org
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