The fat mass and obesity related gene polymorphism influences the risk of rejection in heart transplant patients
Language English Country Denmark Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
30408245
DOI
10.1111/ctr.13443
Knihovny.cz E-resources
- Keywords
- fat mass and obesity related gene, heart transplantation, rejection, single nucleotide polymorphism,
- MeSH
- Alpha-Ketoglutarate-Dependent Dioxygenase FTO genetics MeSH
- Genotype MeSH
- Polymorphism, Single Nucleotide * MeSH
- Middle Aged MeSH
- Humans MeSH
- Follow-Up Studies MeSH
- Postoperative Complications diagnosis etiology genetics MeSH
- Graft Survival MeSH
- Prognosis MeSH
- Graft Rejection diagnosis etiology genetics MeSH
- Risk Factors MeSH
- Heart Transplantation adverse effects MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- FTO protein, human MeSH Browser
- Alpha-Ketoglutarate-Dependent Dioxygenase FTO MeSH
Heart transplantation is a relatively common treatment for end-stage heart failure. The major complication of heart transplantation is organ rejection. Epigenetic could play a role in the pathogenesis of organ rejection, and the FTO gene is a mediator of DNA methylation. We analyzed a tagging FTO SNP rs17817449 in both donor and recipient DNA obtained through 370 heart transplantations. Recipient FTO genotypes were not associated with either type of rejection or with the general increase in the risk of rejection. When compared with patients without a history of rejection, carriers of transplanted hearts with the FTO TT genotype exhibited a significantly increased risk (P = 0.02) of suffering from both types of rejection in comparison to carriers of hearts with at least one G allele (OR; 95% CI = 2.56; 1.15-5.69). Our results suggest that the donor, but not the recipient, FTO genotype could be a significant predictor of acute rejection in heart transplant patients.
Cardio Centre Institute for Clinical and Experimental Medicine Prague Czech Republic
Statistic Unit Institute for Clinical and Experimental Medicine Prague Czech Republic
References provided by Crossref.org
Epitranscriptomic Regulations in the Heart
RNA modification m6Am: the role in cardiac biology
