Molecular mechanisms of polymyxin resistance and detection of mcr genes
Language English Country Czech Republic Media print-electronic
Document type Journal Article, Review
PubMed
30439931
DOI
10.5507/bp.2018.070
Knihovny.cz E-resources
- Keywords
- LPS, colistin, polymyxin, resistance,
- MeSH
- Anti-Bacterial Agents pharmacology MeSH
- Drug Resistance, Bacterial drug effects genetics MeSH
- Bacterial Proteins drug effects genetics MeSH
- Gram-Negative Bacterial Infections drug therapy genetics MeSH
- Colistin pharmacology MeSH
- Humans MeSH
- Microbial Sensitivity Tests MeSH
- Polymyxins pharmacology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- Anti-Bacterial Agents MeSH
- Bacterial Proteins MeSH
- Colistin MeSH
- Polymyxins MeSH
Antibiotic resistance is an ever-increasing global problem. Major commercial antibiotics often fail to fight common bacteria, and some pathogens have become multi-resistant. Polymyxins are potent bactericidal antibiotics against gram-negative bacteria. Known resistance to polymyxin includes intrinsic, mutational and adaptive mechanisms, with the recently described horizontally acquired resistance mechanisms. In this review, we present several strategies for bacteria to develop enhanced resistance to polymyxins, focusing on changes in the outer membrane, efflux and other resistance determinants. Better understanding of the genes involved in polymyxin resistance may pave the way for the development of new and effective antimicrobial agents. We also report novel in silico tested primers for PCR assay that may be able distinguish colistin-resistant isolates carrying the plasmid-encoded mcr genes and will assist in combating the spread of colistin resistance in bacteria.
References provided by Crossref.org
In Silico Analysis of Extended-Spectrum β-Lactamases in Bacteria
