MicroRNAs in the diagnosis and prevention of drug-induced cardiotoxicity
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
Grantová podpora
814316
Grant Agency of Charles University - International
SVV 260 416
Univerzita Karlova v Praze - International
CZ.02.1.01/0.0/0.0/16_019/0000841
EFSA-CDN-ERDF - International
PubMed
30460422
DOI
10.1007/s00204-018-2356-z
PII: 10.1007/s00204-018-2356-z
Knihovny.cz E-zdroje
- Klíčová slova
- Biomarkers, Cardiotoxicity, Circulating microRNA, Doxorubicin,
- MeSH
- biologické markery MeSH
- kardiotoxicita diagnóza genetika MeSH
- lidé MeSH
- mikro RNA genetika MeSH
- nežádoucí účinky léčiv diagnóza genetika MeSH
- srdce účinky léků MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- biologické markery MeSH
- mikro RNA MeSH
Drug-induced cardiotoxicity is a serious problem associated with the administration of many drugs. MicroRNAs (miRNAs) have been reported to be affected by drugs and other xenobiotics, and the potential of miRNAs as biomarkers and diagnostic tools has been considered. In recent years, an association of certain miRNAs with the cardiotoxicity of some drugs, namely anthracyclines, bevacizumab, cyclosporine A and isoprenaline, has already been found. This review article summarizes available information about the changes in miRNA levels induced by cardiotoxic drugs. Three aspects are discussed: the altered expression of miRNAs in the heart upon treatment with cardiotoxic drugs, circulating miRNAs as promising early biomarkers of cardiotoxicity, and the potential of miRNAs in the prevention and/or attenuation of drug-induced cardiotoxicity. The targeted changes in the level of certain miRNAs by antagomiRs and miRNA mimics are also described and evaluated. In addition, the cardioprotective mechanism of various natural compounds via their effect on miRNA levels are examined.
Faculty of Medicine in Hradec Králové Charles University Šimkova 870 Hradec Králové Czech Republic
Faculty of Pharmacy Charles University Akademika Heyrovského 1203 Hradec Králové Czech Republic
Citace poskytuje Crossref.org
MicroRNAs in doxorubicin-induced cardiotoxicity: The DNA damage response
