L1CAM as a Negative Prognostic Factor in Endometrioid Endometrial Adenocarcinoma FIGO Stage IA-IB
Language English Country Greece Media print
Document type Journal Article
PubMed
30591489
DOI
10.21873/anticanres.13128
PII: 39/1/421
Knihovny.cz E-resources
- Keywords
- Endometrial cancer, L1CAM, early stage, recurrence,
- MeSH
- Cell Adhesion MeSH
- Progression-Free Survival MeSH
- Adult MeSH
- Carcinoma, Endometrioid epidemiology genetics pathology MeSH
- Middle Aged MeSH
- Humans MeSH
- Neoplasm Recurrence, Local epidemiology genetics pathology MeSH
- Neural Cell Adhesion Molecule L1 genetics MeSH
- Biomarkers, Tumor genetics MeSH
- Endometrial Neoplasms epidemiology genetics pathology MeSH
- Prognosis MeSH
- Disease Progression MeSH
- Gene Expression Regulation, Neoplastic MeSH
- Aged MeSH
- Neoplasm Staging MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Neural Cell Adhesion Molecule L1 MeSH
- Biomarkers, Tumor MeSH
AIMS: In this study, we aimed to investigate how positivity for L1 cell adhesion molecule (L1CAM) was associated with outcome and relapse pattern in patients with Fédération Internationale de Gynécologie et d'Obstétrique (FIGO) stage IA-IB endometrial cancer. MATERIALS AND METHODS: This retrospective study included 358 patients who underwent surgical treatment for endometrial carcinoma. Tumor samples from 312 patients (87.2%) were available for L1CAM analysis by immunohistochemistry. RESULTS: Of the 312 tumor samples analyzed, 93 (29.8%) were L1CAM-positive. L1CAM positivity was significantly more common in grade 3 compared to grade 1-2 carcinomas (p=0.02). Patients with L1CAM positivity more commonly experienced disease progression. Distant metastasis was significantly associated with L1CAM positivity (p=0.01). Progression-free interval and overall survival did not significantly differ between L1CAM-positive and L1CAM-negative cases. CONCLUSION: L1CAM is a promising independent prognostic marker associated with aggressive tumor behavior and recurrence risk, but not with overall survival.
Department of Obstetrics and Gynecology University Hospital Ostrava Ostrava Poruba Czech Republic
Institute of Pathology University Hospital Ostrava Ostrava Poruba Czech Republic
References provided by Crossref.org
L1CAM Is Not a Predictive Factor in Early-stage Squamous-cell Cervical Cancer
