L1CAM as a Negative Prognostic Factor in Endometrioid Endometrial Adenocarcinoma FIGO Stage IA-IB
Jazyk angličtina Země Řecko Médium print
Typ dokumentu časopisecké články
PubMed
30591489
DOI
10.21873/anticanres.13128
PII: 39/1/421
Knihovny.cz E-zdroje
- Klíčová slova
- Endometrial cancer, L1CAM, early stage, recurrence,
- MeSH
- buněčná adheze MeSH
- doba přežití bez progrese choroby MeSH
- dospělí MeSH
- endometroidní karcinom epidemiologie genetika patologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- lokální recidiva nádoru epidemiologie genetika patologie MeSH
- molekula buněčné adheze nervové L1 genetika MeSH
- nádorové biomarkery genetika MeSH
- nádory endometria epidemiologie genetika patologie MeSH
- prognóza MeSH
- progrese nemoci MeSH
- regulace genové exprese u nádorů MeSH
- senioři MeSH
- staging nádorů MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- molekula buněčné adheze nervové L1 MeSH
- nádorové biomarkery MeSH
AIMS: In this study, we aimed to investigate how positivity for L1 cell adhesion molecule (L1CAM) was associated with outcome and relapse pattern in patients with Fédération Internationale de Gynécologie et d'Obstétrique (FIGO) stage IA-IB endometrial cancer. MATERIALS AND METHODS: This retrospective study included 358 patients who underwent surgical treatment for endometrial carcinoma. Tumor samples from 312 patients (87.2%) were available for L1CAM analysis by immunohistochemistry. RESULTS: Of the 312 tumor samples analyzed, 93 (29.8%) were L1CAM-positive. L1CAM positivity was significantly more common in grade 3 compared to grade 1-2 carcinomas (p=0.02). Patients with L1CAM positivity more commonly experienced disease progression. Distant metastasis was significantly associated with L1CAM positivity (p=0.01). Progression-free interval and overall survival did not significantly differ between L1CAM-positive and L1CAM-negative cases. CONCLUSION: L1CAM is a promising independent prognostic marker associated with aggressive tumor behavior and recurrence risk, but not with overall survival.
Department of Obstetrics and Gynecology University Hospital Ostrava Ostrava Poruba Czech Republic
Institute of Pathology University Hospital Ostrava Ostrava Poruba Czech Republic
Citace poskytuje Crossref.org
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