PURPOSE: This review focuses on the most common drugs administered to surgical patients during the perioperative period that affect the risk of venous thromboembolism (VTE). RESULTS: Among analgesics, the risk of VTE is increased in patients treated with diclofenac, ibuprofen, and rofecoxib, but not naproxen, while metamizole can confer a protective effect. The relationship between sedatives and VTE has not been sufficiently studied. Tricyclic antidepressants, low-potency serotonin reuptake inhibitors, and antipsychotics have been associated with increased risk of VTE. The use of diuretics in the perioperative period is poorly researched; however, hyponatremia is considered a risk factor. Other factors that may influence the risk of VTE include bridging anticoagulation, allogeneic transfusion, and hemostatic management before surgery. Pharmacotherapy for HIV or cancer may also increase VTE risk. CONCLUSION: Increased monitoring for VTE is therefore advisable in surgical patients and those receiving antipsychotics, antidepressants, diuretics, or analgesics.

1st Department of Internal Medicine Faculty of Medicine University Hospital and Comenius University in Bratislava Mickiewiczova 2247 13 811 07 Bratislava Slovakia

1st Department of Surgery Faculty of Medicine Pavol Jozef Safarik University and University Hospital 041 66 Kosice Slovak Republic

2nd Department of Surgery Faculty of Medicine Masaryk University and St Anne's University Hospital Brno Czech Republic

Department of Biopharmaceutics and Pharmacokinetics Faculty of Pharmacy University of Ljubljana Ljubljana Slovenia

Department of Experimental Carcinogenesis Division of Oncology Biomedical Center Martin Jessenius Faculty of Medicine Comenius University in Bratislava 036 01 Martin Slovakia

Department of Internal Medicine Brothers of Mercy Hospital Brno Polni 3 63900 Brno Czech Republic

Department of Medical Biology Jessenius Faculty of Medicine Comenius University in Bratislava Malá Hora 4 036 01 Martin Slovakia

Faculty of Medicine University of Ljubljana Vrazov trg 2 SI 1104 Ljubljana Slovenia

Faculty of Medicine University of Oviedo Central University Hospital of Asturias Oviedo Spain

Murska Sobota General Hospital Murska Sobota Slovenia

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