Comparison of Active Substance Losses and Total Weight Losses of Tablets Administered Via Feeding Tube
Jazyk angličtina Země Švýcarsko Médium print-electronic
Typ dokumentu srovnávací studie, zprávy, validační studie
PubMed
30726848
DOI
10.1159/000496423
PII: 000496423
Knihovny.cz E-zdroje
- Klíčová slova
- Dosage forms, Drug administration routes, High-pressure liquid chromatography, Intensive care, Nasogastric tube,
- MeSH
- enterální výživa přístrojové vybavení MeSH
- enterosolventní tablety MeSH
- gastrointestinální intubace * MeSH
- klopidogrel aplikace a dávkování chemie MeSH
- pantoprazol aplikace a dávkování chemie MeSH
- spektrofotometrie ultrafialová metody MeSH
- tablety MeSH
- vysokoúčinná kapalinová chromatografie metody MeSH
- Publikační typ
- srovnávací studie MeSH
- validační studie MeSH
- zprávy MeSH
- Názvy látek
- enterosolventní tablety MeSH
- klopidogrel MeSH
- pantoprazol MeSH
- tablety MeSH
BACKGROUND/AIMS: Administration of tablets via feeding tube (FT) is often associated with significant drug losses, as was confirmed by weighing. The aim of this study was to measure the proportion of active substance losses (ASLs) in an in vitro model. METHODS: A film-coated tablet (FilmCT) containing clopidogrel (Trombex®) and a tablet with enteric coating (EntericCT) containing pantoprazole (Controloc®) were crushed in a mortar and transferred by method A (tablet powder was transferred into the beaker, poured into the syringe and water added) and method B (water was added into the mortar, suspension drawn into the syringe) and administered via FT in an in vitro model. Total losses were measured with analytical balance and, simultaneously, ASL were analyzed with high-performance liquid chromatography UV-detection (HPLC-UV). RESULTS: ASL was different to weighing only in the case of EntericCT prepared by method B (2.0 ± 4.2 and 10.7 ± 0.8% for HPLC-UV and weighing, respectively; p = 0.004). HPLC-UV confirmed significantly lower ASL when method B was used for either EntericCT (34.3 ± 7.2 vs. 2.0 ± 4.2%; p < 0.001) or FilmCT (14.1 ± 2.2 vs. 7.7 ± 4.1%; p < 0.01). CONCLUSION: Drug loss analysis with analytical balance may overestimate ASL, as was proved for EntericCT in this study. ASL were significantly lower when method B was used.
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