Different immune response of dendritic cells of newborns of allergic and healthy mothers to bacterial stimuli
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články
Grantová podpora
AZV 15-26877A
Agentura Pro Zdravotnický Výzkum České Republiky
PubMed
30850938
DOI
10.1007/s12223-019-00693-4
PII: 10.1007/s12223-019-00693-4
Knihovny.cz E-zdroje
- MeSH
- alergie krev diagnóza MeSH
- antigeny bakteriální imunologie MeSH
- antigeny povrchové genetika metabolismus MeSH
- biologické markery metabolismus MeSH
- cytokiny genetika metabolismus MeSH
- dendritické buňky imunologie MeSH
- fetální krev MeSH
- kultivované buňky MeSH
- lidé MeSH
- matky MeSH
- monocyty imunologie MeSH
- novorozenec MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- novorozenec MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antigeny bakteriální MeSH
- antigeny povrchové MeSH
- biologické markery MeSH
- cytokiny MeSH
Continuous increasing incidence of allergic diseases is calling for identifying early prognostic markers pointing to increased risk of allergy development and establishing protocols for preventive strategies limiting allergy development in predisposed individuals. It is important to better understand the critical events occurring in early postnatal life, especially the interaction of a newborn with microbial compounds important for the maturation of the neonatal immune system and setting immunoregulatory responses as well. Dendritic cells (DC) together with the cytokine microenvironment play an important role in priming of immune responses. The capacity of monocyte-derived DC (moDC) from cord blood of children of healthy and allergic mothers to respond to microbial antigens (Escherichia coli O86 (EcO86) and delipidated Bacillus firmus (DBF)) was tested by flow cytometry and quantitative real-time PCR. Both EcO86 and DBF were able to promote maturation of moDC, but moDC of children of allergic mothers expressed higher levels of activation markers CD80 and CD83. Increased gene expression of IL-6 and lower expression of indol-amine 2,3 dioxygenase were observed in moDC of neonates of allergic mothers, in comparison to healthy ones. A higher gene expression and an increased presence of activation markers on moDC of newborns of allergic mothers indicate a generally higher reactivity of these cells, possibly enabling easier development of inappropriate immune response after an allergen encounter.
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