Automated Family-Wide Annotation of Secondary Structure Elements
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
- Keywords
- Annotation, Protein domain, Protein family, SecStrAnnotator, Secondary structure, Secondary structure assignment, Secondary structure elements, Structural alignment,
- MeSH
- Algorithms MeSH
- Amino Acid Motifs * MeSH
- Molecular Sequence Annotation methods MeSH
- Catalytic Domain genetics MeSH
- Proteins chemistry genetics MeSH
- Software MeSH
- Computational Biology methods MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Proteins MeSH
Secondary structure elements (SSEs) are inherent parts of protein structures, and their arrangement is characteristic for each protein family. Therefore, annotation of SSEs can facilitate orientation in the vast number of homologous structures which is now available for many protein families. It also provides a way to identify and annotate the key regions, like active sites and channels, and subsequently answer the key research questions, such as understanding of molecular function and its variability.This chapter introduces the concept of SSE annotation and describes the workflow for obtaining SSE annotation for the members of a selected protein family using program SecStrAnnotator.
CEITEC Central European Institute of Technology Masaryk University Brno Czech Republic
Faculty of Informatics Masaryk University Brno Czech Republic
Faculty of Science National Centre for Biomolecular Research Masaryk University Brno Czech Republic
References provided by Crossref.org
2DProts: database of family-wide protein secondary structure diagrams
