Determinants of CAT (COPD Assessment Test) scores in a population of patients with COPD in central and Eastern Europe: The POPE study
Language English Country Great Britain, England Media print-electronic
Document type Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Observational Study, Research Support, Non-U.S. Gov't
PubMed
30961941
DOI
10.1016/j.rmed.2019.03.007
PII: S0954-6111(19)30082-4
Knihovny.cz E-resources
- Keywords
- CAT, COPD, Comorbidities, GOLD classification, mMRC,
- MeSH
- Pulmonary Disease, Chronic Obstructive diagnosis epidemiology physiopathology therapy MeSH
- Depression epidemiology MeSH
- Physical Endurance physiology MeSH
- Comorbidity MeSH
- Middle Aged MeSH
- Humans MeSH
- Prevalence MeSH
- Cross-Sectional Studies MeSH
- Respiratory Function Tests methods MeSH
- Aged MeSH
- Severity of Illness Index MeSH
- Walk Test methods MeSH
- Symptom Assessment methods MeSH
- Forced Expiratory Volume physiology MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Clinical Trial MeSH
- Multicenter Study MeSH
- Observational Study MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Geographicals
- Bulgaria epidemiology MeSH
- Hungary epidemiology MeSH
- Europe, Eastern epidemiology MeSH
BACKGROUND: The COPD Assessment Test (CAT) has been proposed to help guide therapy in chronic obstructive pulmonary disease (COPD). It is important to understand the distribution of scores in different COPD populations and their determinants. METHODS: The POPE study is an international, observational cross-sectional study of COPD subjects in 11 Central and Eastern European countries aimed at characterizing COPD phenotypes. Here we report the analysis of CAT scores with the objective of identifying their determinants, evaluating symptom load and investigating the distribution of scores among the participating countries. Additionally, we investigated the discrepancies between the CAT and modified Medical Research Council (mMRC) scores when used to classify patients according to the GOLD strategy. RESULTS: The study included 3452 patients (69.2% men, mean forced expiratory volume in 1 s (FEV1% predicted) 52.5%). The mean CAT score was 17.5 (SD = 7.8), ranging from 15.1 in Hungary to 21.2 in Bulgaria. Multiple linear regression analysis showed six variables significantly associated with CAT scores: depression, number of previous exacerbations, 6-min walking distance, FEV1(%), mMRC and country and explained 47.2% of the variance of CAT. According to either CAT or mMRC, up to 23.9% patients would be classified in different GOLD groups. CONCLUSIONS: The CAT score may be predicted by factors related to COPD severity, depression and exercise capacity, with significant differences in the distribution of CAT scores in different countries. According to our results CAT >10 is not equivalent to mMRC >2 for assessing symptom burden. TRIAL REGISTRATION: ClinicalTrials.gov, identifier NCT02119494.
Clinic for Pulmonary Diseases Faculty of Medicine Clinical Center of Serbia Belgrade Serbia
Clinic of Pulmonary Diseases Military Medical Academy Sofia Bulgaria
Department of Pulmonology University of Szeged Deszk Hungary
Faculty of Medicine University of Latvia Riga Latvia; Riga East University Hospital Latvia
Institute of Biostatistics and Analyses Faculty of Medicine Masaryk University Brno Czech Republic
Pulmonary Department Topolsica Hospital Topolsica Slovenia
School of Medicine Zagreb University Hospital Dubrava Zagreb Croatia
References provided by Crossref.org
ClinicalTrials.gov
NCT02119494
