DNA methylation and chromatin modifiers in colorectal cancer
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
31028771
DOI
10.1016/j.mam.2019.04.002
PII: S0098-2997(19)30008-1
Knihovny.cz E-resources
- Keywords
- Chromatin remodeling, Colorectal cancer, DNA methylation, Epigenetics, Epithelial-to-mesenchymal transition, Histone modifications, Prognosis, Stemness, miRNA,
- MeSH
- Chromatin genetics metabolism MeSH
- Epigenesis, Genetic * MeSH
- Epithelial-Mesenchymal Transition MeSH
- Epistasis, Genetic MeSH
- Histones metabolism MeSH
- Colorectal Neoplasms genetics metabolism pathology MeSH
- Humans MeSH
- DNA Methylation * MeSH
- Cell Transformation, Neoplastic genetics metabolism MeSH
- Protein Processing, Post-Translational MeSH
- Disease Progression MeSH
- Gene Expression Regulation, Neoplastic MeSH
- Chromatin Assembly and Disassembly genetics MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Chromatin MeSH
- Histones MeSH
Colorectal carcinogenesis is a multistep process involving the accumulation of genetic alterations over time that ultimately leads to disease progression and metastasis. Binding of transcription factors to gene promoter regions alone cannot explain the complex regulation pattern of gene expression during this process. It is the chromatin structure that allows for a high grade of regulatory flexibility for gene expression. Posttranslational modifications on histone proteins such as acetylation, methylation, or phosphorylation determine the accessibility of transcription factors to DNA. DNA methylation, a chemical modification of DNA that modulates chromatin structure and gene transcription acts in concert with these chromatin conformation alterations. Another epigenetic mechanism regulating gene expression is represented by small non-coding RNAs. Only very recently epigenetic alterations have been included in molecular subtype classification of colorectal cancer (CRC). In this chapter, we will provide examples of the different epigenetic players, focus on their role for epithelial-mesenchymal transition and metastatic processes and discuss their prognostic value in CRC.
References provided by Crossref.org
Methylation-Based Therapies for Colorectal Cancer
Colorectal Adenomas-Genetics and Searching for New Molecular Screening Biomarkers
