DNA methylation and chromatin modifiers in colorectal cancer
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
31028771
DOI
10.1016/j.mam.2019.04.002
PII: S0098-2997(19)30008-1
Knihovny.cz E-zdroje
- Klíčová slova
- Chromatin remodeling, Colorectal cancer, DNA methylation, Epigenetics, Epithelial-to-mesenchymal transition, Histone modifications, Prognosis, Stemness, miRNA,
- MeSH
- chromatin genetika metabolismus MeSH
- epigeneze genetická * MeSH
- epitelo-mezenchymální tranzice MeSH
- genetická epistáze MeSH
- histony metabolismus MeSH
- kolorektální nádory genetika metabolismus patologie MeSH
- lidé MeSH
- metylace DNA * MeSH
- nádorová transformace buněk genetika metabolismus MeSH
- posttranslační úpravy proteinů MeSH
- progrese nemoci MeSH
- regulace genové exprese u nádorů MeSH
- restrukturace chromatinu genetika MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- chromatin MeSH
- histony MeSH
Colorectal carcinogenesis is a multistep process involving the accumulation of genetic alterations over time that ultimately leads to disease progression and metastasis. Binding of transcription factors to gene promoter regions alone cannot explain the complex regulation pattern of gene expression during this process. It is the chromatin structure that allows for a high grade of regulatory flexibility for gene expression. Posttranslational modifications on histone proteins such as acetylation, methylation, or phosphorylation determine the accessibility of transcription factors to DNA. DNA methylation, a chemical modification of DNA that modulates chromatin structure and gene transcription acts in concert with these chromatin conformation alterations. Another epigenetic mechanism regulating gene expression is represented by small non-coding RNAs. Only very recently epigenetic alterations have been included in molecular subtype classification of colorectal cancer (CRC). In this chapter, we will provide examples of the different epigenetic players, focus on their role for epithelial-mesenchymal transition and metastatic processes and discuss their prognostic value in CRC.
Citace poskytuje Crossref.org
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