BACKGROUND: Idiopathic rapid eye movement sleep behavior disorder (iRBD) affects 1-2% of people over 60 years of age and presents a high risk of developing a neurodegenerative disorder from the group of synucleinopathies, such as Parkinson's disease, dementia with Lewy bodies and multiple system atrophy. Therefore, screening tools are needed. In 2007, the rapid eye movement sleep behavior disorder screening questionnaire (RBD-SQ) was developed and has been translated into several languages. The aim of study was to assess the validity and reliability of the Czech version of the RBD-SQ in a mixed population of sleep clinic patients, supplemented by healthy volunteers and RBD patients. METHODS: Participants included 81 iRBD patients, 205 patients with other sleep disorders (obstructive sleep apnea, insomnia, restless legs syndrome and periodic limb movement disorder, other parasomnias, or central hypersomnias including narcolepsy) and 20 healthy volunteers. RESULTS: The mean RBD-SQ score in the iRBD patients was 9.4 ± 2.8 points, and in the non-RBD group it was 4.5 ± 3.0 (P < 0.0001). Receiver -operator analysis yielded an area under the curve of 0.864, suggesting good diagnostic performance of the scale. When using a cut-off value for positivity of 5 points, sensitivity was 0.89 and specificity was 0.62. CONCLUSIONS: The Czech version of the RBD-SQ is a sensitive tool for screening for iRBD patients and helps to identify subjects for complete clinical workup.

Department of Neurology and Center of Clinical Neurosciences 1stFaculty of Medicine Charles University Kateřinská 30 12000 Praha 2 Czech Republic

Department of Sleep Medicine National Institute of Mental Health Klecany Czech Republic

See more in PubMed

American Academy of Sleep Medicine. International Classification of Sleep Disorders. 3rd ed. Darien, IL; 2014.

Kang SH, Yoon IY, Lee SD, Han JW, Kim TH, Kim KW. REM sleep behavior disorder in the Korean elderly population: prevalence and clinical characteristics. Sleep. 2013;36(8):1147–1152. doi: 10.5665/sleep.2874. PubMed DOI PMC

Pujol M, Pujol J, Alonso T, Fuentes A, Pallerola M, Freixenet J, Barbe F, Salamero M, Santamaria J, Iranzo A. Idiopathic REM sleep behavior disorder in the elderly Spanish community: a primary care center study with a two-stage design using video-polysomnography. Sleep Med. 2017;40:116–121. doi: 10.1016/j.sleep.2017.07.021. PubMed DOI

Iranzo A, Fernandez-Arcos A, Tolosa E, Serradell M, Molinuevo JL, Valldeoriola F, Gelpi E, Vilaseca I, Sanchez-Valle R, Llado A, et al. Neurodegenerative disorder risk in idiopathic REM sleep behavior disorder: study in 174 patients. PLoS One. 2014;9(2):e89741. doi: 10.1371/journal.pone.0089741. PubMed DOI PMC

Iranzo A, Molinuevo JL, Santamaria J, Serradell M, Marti MJ, Valldeoriola F, Tolosa E. Rapid-eye-movement sleep behaviour disorder as an early marker for a neurodegenerative disorder: a descriptive study. The Lancet Neurology. 2006;5(7):572–577. doi: 10.1016/S1474-4422(06)70476-8. PubMed DOI

Stiasny-Kolster K, Mayer G, Schafer S, Moller JC, Heinzel-Gutenbrunner M, Oertel WH. The REM sleep behavior disorder screening questionnaire--a new diagnostic instrument. Movement disorders : official journal of the Movement Disorder Society. 2007;22(16):2386–2393. doi: 10.1002/mds.21740. PubMed DOI

Tari Comert I, Pelin Z, Aricak T, Yapan S: Validation of the Turkish version of the rapid eye movement sleep behavior disorder questionnaire. Behav Neurol 2016, 2016:8341651. PubMed PMC

Marelli S, Rancoita PM, Giarrusso F, Galbiati A, Zucconi M, Oldani A, Di Serio C, Ferini-Strambi L. National validation and proposed revision of REM sleep behavior disorder screening questionnaire (RBDSQ) J Neurol. 2016;263(12):2470–2475. doi: 10.1007/s00415-016-8285-y. PubMed DOI

Miyamoto T, Miyamoto M, Iwanami M, Kobayashi M, Nakamura M, Inoue Y, Ando C, Hirata K. The REM sleep behavior disorder screening questionnaire: validation study of a Japanese version. Sleep Med. 2009;10(10):1151–1154. doi: 10.1016/j.sleep.2009.05.007. PubMed DOI

Wang Y, Wang ZW, Yang YC, Wu HJ, Zhao HY, Zhao ZX. Validation of the rapid eye movement sleep behavior disorder screening questionnaire in China. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 2015;22(9):1420–1424. doi: 10.1016/j.jocn.2015.03.008. PubMed DOI

You S, Moon HJ, Do SY, Wing YK, Sunwoo JS, Jung KY, Cho YW. The REM sleep behavior disorder screening questionnaire: validation study of the Korean version (RBDQ-KR). J Clin Sleep Med. 2017. PubMed PMC

Li SX, Wing YK, Lam SP, Zhang J, Yu MW, Ho CK, Tsoh J, Mok V. Validation of a new REM sleep behavior disorder questionnaire (RBDQ-HK) Sleep Med. 2010;11(1):43–48. doi: 10.1016/j.sleep.2009.06.008. PubMed DOI

Boeve BF, Molano JR, Ferman TJ, Lin SC, Bieniek K, Tippmann-Peikert M, Boot B, St Louis EK, Knopman DS, Petersen RC, et al. Validation of the Mayo sleep questionnaire to screen for REM sleep behavior disorder in a community-based sample. J Clin Sleep Med. 2013;9(5):475–480. PubMed PMC

Boeve BF, Molano JR, Ferman TJ, Smith GE, Lin SC, Bieniek K, Haidar W, Tippmann-Peikert M, Knopman DS, Graff-Radford NR, et al. Validation of the Mayo sleep questionnaire to screen for REM sleep behavior disorder in an aging and dementia cohort. Sleep Med. 2011;12(5):445–453. doi: 10.1016/j.sleep.2010.12.009. PubMed DOI PMC

Frauscher B, Ehrmann L, Zamarian L, Auer F, Mitterling T, Gabelia D, Brandauer E, Delazer M, Poewe W, Hogl B. Validation of the Innsbruck REM sleep behavior disorder inventory. Movement disorders : official journal of the Movement Disorder Society. 2012;27(13):1673–1678. doi: 10.1002/mds.25223. PubMed DOI

Postuma RB, Arnulf I, Hogl B, Iranzo A, Miyamoto T, Dauvilliers Y, Oertel W, Ju YE, Puligheddu M, Jennum P, et al. A single-question screen for rapid eye movement sleep behavior disorder: a multicenter validation study. Movement disorders : official journal of the Movement Disorder Society. 2012;27(7):913–916. doi: 10.1002/mds.25037. PubMed DOI PMC

Frauscher B, Iranzo A, Gaig C, Gschliesser V, Guaita M, Raffelseder V, Ehrmann L, Sola N, Salamero M, Tolosa E, et al. Normative EMG values during REM sleep for the diagnosis of REM sleep behavior disorder. Sleep. 2012;35(6):835–847. doi: 10.5665/sleep.1886. PubMed DOI PMC

Kopecek M, Stepankova H, Lukavsky J, Ripova D, Nikolai T, Bezdicek O. Montreal cognitive assessment (MoCA): normative data for old and very old Czech adults. Applied neuropsychology Adult. 2017;24(1):23–29. doi: 10.1080/23279095.2015.1065261. PubMed DOI

Buskova J, Ibarburu V, Sonka K, Ruzicka E. Screening for REM sleep behavior disorder in the general population. Sleep Med. 2016;24:147. doi: 10.1016/j.sleep.2016.07.003. PubMed DOI

Bland JM, Altman DG. Cronbach's alpha. BMJ (Clinical research ed) 1997;314(7080):572. doi: 10.1136/bmj.314.7080.572. PubMed DOI PMC

Boeve BF. Idiopathic REM sleep behaviour disorder in the development of Parkinson's disease. The Lancet Neurology. 2013;12(5):469–482. doi: 10.1016/S1474-4422(13)70054-1. PubMed DOI PMC

Gagnon JF, Postuma RB, Mazza S, Doyon J, Montplaisir J. Rapid-eye-movement sleep behaviour disorder and neurodegenerative diseases. The Lancet Neurology. 2006;5(5):424–432. doi: 10.1016/S1474-4422(06)70441-0. PubMed DOI

Nomura T, Inoue Y, Kagimura T, Uemura Y, Nakashima K. Utility of the REM sleep behavior disorder screening questionnaire (RBDSQ) in Parkinson's disease patients. Sleep Med. 2011;12(7):711–713. doi: 10.1016/j.sleep.2011.01.015. PubMed DOI

Frauscher B, Mitterling T, Bode A, Ehrmann L, Gabelia D, Biermayr M, Walters AS, Poewe W, Hogl B. A prospective questionnaire study in 100 healthy sleepers: non-bothersome forms of recognizable sleep disorders are still present. J Clin Sleep Med. 2014;10(6):623–629. PubMed PMC

Mahlknecht P, Seppi K, Frauscher B, Kiechl S, Willeit J, Stockner H, Djamshidian A, Nocker M, Rastner V, Defrancesco M, et al. Probable RBD and association with neurodegenerative disease markers: a population-based study. Movement disorders : official journal of the Movement Disorder Society. 2015;30(10):1417–1421. doi: 10.1002/mds.26350. PubMed DOI

Magnetic susceptibility changes in the brainstem reflect REM sleep without atonia severity in isolated REM sleep behavior disorder