Clear cell renal cell carcinoma with Paneth-like cells: Clinicopathologic, morphologic, immunohistochemical, ultrastructural, and molecular analysis of 13 cases
Language English Country United States Media print-electronic
Document type Journal Article
PubMed
31202196
DOI
10.1016/j.anndiagpath.2019.05.012
PII: S1092-9134(19)30195-9
Knihovny.cz E-resources
- Keywords
- Clear cell renal cell carcinoma, Immunohistochemistry, Kidney, Next generation sequencing, Paneth-like cells,
- MeSH
- Adult MeSH
- Immunohistochemistry MeSH
- Carcinoma, Renal Cell pathology MeSH
- Middle Aged MeSH
- Humans MeSH
- Kidney Neoplasms pathology MeSH
- Paneth Cells pathology MeSH
- Aged MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
Clear cell renal cell carcinoma (CRCC) is well known for its intratumoral heterogeneity. Paneth-like cells (PLC) have been reported in variable organs (i.e., hepatobiliary, genitourinary, and female genital tract). In genitourinary system, it is possible to find PLCs in epididymis, urinary bladder and prostate. The objective of this study was to assess PLC in CRCCs 13 CRCCs with prominent PLC (CRCCPLC) were selected out of 1378 CRCCs in our registry. The tumors were analyzed using morphologic, immunohistochemical, ultrastructural, and molecular genetic methods. CRCCPLCs were mostly of low histologic grade (12/13). Immunohistochemical profile was compatible with classic CRCC. PLC constituted 10 to-70% of the tumor volume (mean 17.7%, median 10%). PLCs did not express neuroendocrine markers (chromogranin, synaptophysin, CD56, INSM-1). Ultrastructurally, PLCs were filled by membrane bounded vesicles of various sizes and were compatible with secretory type of cells. VHL mutation was found in 9/9 cases, and LOH3p was found in 6/8 analyzable cases. Conclusions: PLC morphology can variably be present in "classic" CRCC, even in a substantial proportion. Ultrastructurally, PLCs have all attributes of secretory cells. Preliminary follow up data showed that these tumors may not be associated with aggressive clinical behavior.
Clinical Department of Pathology and Cytology University Hospital Centre Zagreb Croatia
Department of Human Pathology Wakayama Medical University Wakayama Japan
Department of Pathology Charles University Prague Faculty of Medicine in Plzeň Pilsen Czech Republic
Department of Pathology Musashino Red Cross Hospital Tokyo Japan
Department of Urology Charles University Prague Faculty of Medicine in Plzeň Pilsen Czech Republic
Institute of Pathology Hospital and University Clinic Services of Kosovo Prishtina Kosovo
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