Ovarian Cancer: Differentially Expressed microRNAs in Tumor Tissue and Cell-Free Ascitic Fluid as Potential Novel Biomarkers
Language English Country Great Britain, England Media print-electronic
Document type Journal Article
- Keywords
- Ovarian cancer, ascites, effusion, microRNA, tumor,
- MeSH
- Ascitic Fluid chemistry MeSH
- Middle Aged MeSH
- Humans MeSH
- MicroRNAs genetics MeSH
- Biomarkers, Tumor genetics MeSH
- Ovarian Neoplasms genetics pathology MeSH
- Ovary chemistry MeSH
- Prognosis MeSH
- Gene Expression Regulation, Neoplastic MeSH
- Oligonucleotide Array Sequence Analysis methods MeSH
- Aged MeSH
- Neoplasm Staging MeSH
- Gene Expression Profiling methods MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- MicroRNAs MeSH
- MIRN135 microRNA, human MeSH Browser
- Mirn182 microRNA, human MeSH Browser
- MIRN200 microRNA, human MeSH Browser
- MIRN204 microRNA, human MeSH Browser
- MIRN451 microRNA, human MeSH Browser
- Biomarkers, Tumor MeSH
Ovarian cancer is the deadliest gynecologic cancer. The large-scale microRNA (miRNA) expression profiling and individual miRNA validation was performed to find potential novel biomarkers for ovarian cancer. The most consistent overexpression of miRs-200b-3p, 135 b-5p and 182-5p was found in both ascitic fluid and tumors and suggests their potential as oncogenes. miR-451a was consistently underexpressed so may be a tumor suppressor. Results were inconsistent for miR-204-5p, which was overexpressed in ascitic fluid but underexpressed in tumor tissue. miR-203a-3p was generally overexpressed but this failed to be proved in independent sample set in tissue validation.
Department of Pathology Masaryk University and University Hospital Brno Brno Czech Republic
Faculty Transfusion Center General University Hospital Prague Prague 2 Czech Republic
Institute of Experimental Botany Czech Academy of Sciences Prague 6 Czech Republic
References provided by Crossref.org
Emerging biologic and clinical implications of miR-182-5p in gynecologic cancers
