Ovarian Cancer: Differentially Expressed microRNAs in Tumor Tissue and Cell-Free Ascitic Fluid as Potential Novel Biomarkers
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články
- Klíčová slova
- Ovarian cancer, ascites, effusion, microRNA, tumor,
- MeSH
- ascitická tekutina chemie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mikro RNA genetika MeSH
- nádorové biomarkery genetika MeSH
- nádory vaječníků genetika patologie MeSH
- ovarium chemie MeSH
- prognóza MeSH
- regulace genové exprese u nádorů MeSH
- sekvenční analýza hybridizací s uspořádaným souborem oligonukleotidů metody MeSH
- senioři MeSH
- staging nádorů MeSH
- stanovení celkové genové exprese metody MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- mikro RNA MeSH
- MIRN135 microRNA, human MeSH Prohlížeč
- Mirn182 microRNA, human MeSH Prohlížeč
- MIRN200 microRNA, human MeSH Prohlížeč
- MIRN204 microRNA, human MeSH Prohlížeč
- MIRN451 microRNA, human MeSH Prohlížeč
- nádorové biomarkery MeSH
Ovarian cancer is the deadliest gynecologic cancer. The large-scale microRNA (miRNA) expression profiling and individual miRNA validation was performed to find potential novel biomarkers for ovarian cancer. The most consistent overexpression of miRs-200b-3p, 135 b-5p and 182-5p was found in both ascitic fluid and tumors and suggests their potential as oncogenes. miR-451a was consistently underexpressed so may be a tumor suppressor. Results were inconsistent for miR-204-5p, which was overexpressed in ascitic fluid but underexpressed in tumor tissue. miR-203a-3p was generally overexpressed but this failed to be proved in independent sample set in tissue validation.
Department of Pathology Masaryk University and University Hospital Brno Brno Czech Republic
Faculty Transfusion Center General University Hospital Prague Prague 2 Czech Republic
Institute of Experimental Botany Czech Academy of Sciences Prague 6 Czech Republic
Citace poskytuje Crossref.org
Emerging biologic and clinical implications of miR-182-5p in gynecologic cancers
