Background: Necrotizing fasciitis is a major health problem throughout the world. The purpose of this review is to assist providers with the care of these patients through a better understanding of the pathophysiology and management options. Methods: This is a collaborative review of the literature between members of the Surgical Infection Society of North America and World Society of Emergency Surgery. Results: Necrotizing fasciitis continues to be difficult to manage with the mainstay being early diagnosis and surgical intervention. Recognition of at-risk populations assists with the initiation of treatment, thereby impacting outcomes. Conclusions: Although there are some additional treatment strategies available, surgical debridement and antimicrobial therapy are central to the successful eradication of the disease process.

1st Department of Surgery 1st Faculty of Medicine Charles University Prague and General University Hospital Prague Prague Czech Republic

Antimicrobial Stewardship UT Southwestern Dallas Texas

Department of Pediatric Surgery Northwestern University Chicago Illinois

Department of Surgery Macerata Hospital Macerata Italy

Department of Surgery Washington University St Louis Missouri

Division of Infectious Diseases and Geographic Medicine UT Southwestern Dallas Texas

Emergency and Trauma Surgery Department Parma University Hospital Parma Italy

Envision Healthcare Dallas Texas

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