Chronic inflammation with a wide spectrum of connected diseases (e [...].

Department of Molecular Biology Institute of Genetics and Animal Breeding of the Polish Academy of Sciences 05 552 Jastrzębiec Poland

Department of Natural Drugs Faculty of Pharmacy University of Veterinary and Pharmaceutical Sciences Brno Palackého 1946 1 61242 Brno Czech Republic

Department of Pharmacognosy University of Vienna Althanstrasse 14 1090 Vienna Austria

Institute of Clinical Chemistry University Hospital Zurich University of Zurich Wagistrasse 14 8952 Schlieren Switzerland

Institute of Neurobiology Bulgarian Academy of Sciences 23 Acad G Bonchevstr 1113 Sofia Bulgaria

The 2nd Affiliated Hospital of Guizhou University of Traditional Chinese Medicine Fei Shan Jie 32 550003 Guiyang China

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Pahwa R., Jialal I. Chronic Inflammation. StatPearls Publishing; Treasure Island, FL, USA: 2019. PubMed

Marrero-Ponce Y., Siverio-Mota D., Galvez-Llompart M., Recio M.C., Giner R.M., Garcia-Domenech R., Torrens F., Aran V.J., Cordero-Maldonado M.L., Esguera C.V., et al. Discovery of Novel Anti-Inflammatory Drug-Like Compounds by Aligning in Silico and In Vivo Screening: The Nitroindazolinone Chemotype. Eur. J. Med. Chem. 2011;46:5736–5753. doi: 10.1016/j.ejmech.2011.07.053. PubMed DOI

Tran T.V., Malainer C., Schwaiger S., Hung T., Atanasov A.G., Heiss E.H., Dirsch V.M., Stuppner H. Screening of Vietnamese Medicinal Plants for NF-KappaB Signaling Inhibitors: Assessing the Activity of Flavonoids from the Stem Bark of Oroxylum Indicum. J. Ethnopharmacol. 2015;159:36–42. doi: 10.1016/j.jep.2014.10.012. PubMed DOI PMC

Nöst X., Pferschy-Wenzig E.-M., Nikles S., He X., Fan D., Lu A., Yuk J., Yu K., Isaac G., Bauer R. Identification of Constituents Affecting the Secretion of Pro-Inflammatory Cytokines in LPS-Induced U937 Cells by UHPLC-HRMS-Based Metabolic Profiling of the Traditional Chinese Medicine Formulation Huangqi Jianzhong Tang. Molecules. 2019;24:3116. doi: 10.3390/molecules24173116. PubMed DOI PMC

Wallace K.L., Riedel A.A., Joseph-Ridge N., Wortmann R. Increasing Prevalence of Gout and Hyperuricemia over 10 Years among Older Adults in a Managed Care Population. J. Rheumatol. 2004;31:1582–1587. PubMed

Lee H.E., Yang G., Park Y.B., Kang H.C., Cho Y.Y., Lee H.S., Lee J.Y. Epigallocatechin-3-Gallate Prevents Acute Gout by Suppressing NLRP3 Inflammasome Activation and Mitochondrial DNA Synthesis. Molecules. 2019;24:2138. doi: 10.3390/molecules24112138. PubMed DOI PMC

Ragab G., Elshahaly M., Bardin T. Gout: An Old Disease in New Perspective—A Review. J. Adv. Res. 2017;8:495–511. doi: 10.1016/j.jare.2017.04.008. PubMed DOI PMC

Hou Y.X., Sun S.W., Liu Y., Li Y., Liu X.H., Wang W., Zhang S., Wang W. An Improved Method for the Synthesis of Butein Using SOCl2/EtOH as Catalyst and Deciphering Its Inhibition Mechanism on Xanthine Oxidase. Molecules. 2019;24:1948. doi: 10.3390/molecules24101948. PubMed DOI PMC

Kang N.S., Park S.Y., Lee K.R., Lee S.M., Lee B.G., Shin D.H., Pyo S. Modulation of Macrophage Function Activity by Ethanolic Extract of Larvae of Holotrichia Diomphalia. J. Ethnopharmacol. 2002;79:89–94. doi: 10.1016/S0378-8741(01)00369-5. PubMed DOI

Hong J.H., Kim S.H., Lee Y.C. The Ethanol Extract of Holotrichia diomphalia Larvae, Containing Fatty acids and Amino acids, Exerts Anti-Asthmatic Effects through Inhibition of the GATA-3/Th2 Signaling Pathway in Asthmatic Mice. Molecules. 2019;24:852. doi: 10.3390/molecules24050852. PubMed DOI PMC

Huminiecki L., Horbanczuk J., Atanasov A.G. The Functional Genomic Studies of Curcumin. Semin. Cancer Biol. 2017;46:107–118. doi: 10.1016/j.semcancer.2017.04.002. PubMed DOI

Pagano E., Romano B., Izzo A.A., Borrelli F. The Clinical Efficacy of Curcumin-Containing Nutraceuticals: An Overview of Systematic Reviews. Pharm. Res. 2018;134:79–91. doi: 10.1016/j.phrs.2018.06.007. PubMed DOI

Mollazadeh H., Cicero A.F.G., Blesso C.N., Pirro M., Majeed M., Sahebkar A. Immune Modulation by Curcumin: The Role of Interleukin-10. Crit. Rev. Food Sci. Nutr. 2019;59:89–101. doi: 10.1080/10408398.2017.1358139. PubMed DOI

Yeung A.W.K., Bhushan B., Barreca D., Battino M., Belwal T., Horbańczuk O., Berindan-Neagoe I., Bishayee A., Daglia M., Devkota H., et al. Dietary Natural Products and their Potential to Influence Health and Disease including Animal Models. Anim. Sci. Pap. Rep. 2018;36:345–358.

Yeung A.W.K., Horbanczuk M., Tzvetkov N.T., Mocan A., Carradori S., Maggi F., Marchewka J., Sut S., Dall’Acqua S., Gan R.Y., et al. Curcumin: Total-Scale Analysis of the Scientific Literature. Molecules. 2019;24:1393. doi: 10.3390/molecules24071393. PubMed DOI PMC

Cao B., Wang Y., Ding K., Neamati N., Long Y.Q. Synthesis of the Pyridinyl Analogues of Dibenzylideneacetone (pyr-dba) via an Improved Claisen-Schmidt Condensation, Displaying Diverse Biological Activities as Curcumin Analogues. Org. Biomol. Chem. 2012;10:1239–1245. doi: 10.1039/C1OB06773G. PubMed DOI

Hisamuddin N., Shaik Mossadeq W.M., Sulaiman M.R., Abas F., Leong S.W., Kamarudin N., Ong H.M., Ahmad Azmi A.F., Ayumi R.R., Talib M. Anti-Edematogenic and Anti-Granuloma Activity of a Synthetic Curcuminoid Analog, 5-(3,4-Dihydroxyphenyl)-3-hydroxy-1-(2-hydroxyphenyl) penta-2,4-dien-1-one, in Mouse Models of Inflammation. Molecules. 2019;24:2614. doi: 10.3390/molecules24142614. PubMed DOI PMC

Nitiss J.L. Targeting DNA Topoisomerase II in Cancer Chemotherapy. Nat. Rev. Cancer. 2009;9:338–350. doi: 10.1038/nrc2607. PubMed DOI PMC

Moosavi M.A., Haghi A., Rahmati M., Taniguchi H., Mocan A., Echeverria J., Gupta V.K., Tzvetkov N.T., Atanasov A.G. Phytochemicals as Potent Modulators of Autophagy for Cancer Therapy. Cancer Lett. 2018;424:46–69. doi: 10.1016/j.canlet.2018.02.030. PubMed DOI

Kamb A., Wee S., Lengauer C. Why is Cancer Drug Discovery so Difficult? Nat. Rev. Drug Discov. 2007;6:115–120. doi: 10.1038/nrd2155. PubMed DOI

Mrkvova Z., Uldrijan S., Pombinho A., Bartunek P., Slaninova I. Benzimidazoles Downregulate Mdm2 and MdmX and Activate p53 in MdmX Overexpressing Tumor Cells. Molecules. 2019;24:2152. doi: 10.3390/molecules24112152. PubMed DOI PMC

Mantovani A., Sica A., Sozzani S., Allavena P., Vecchi A., Locati M. The Chemokine System in Diverse forms of Macrophage Activation and Polarization. Trends Immunol. 2004;25:677–686. doi: 10.1016/j.it.2004.09.015. PubMed DOI

Wei W., Li Z.P., Bian Z.X., Han Q.B. Astragalus Polysaccharide RAP Induces Macrophage Phenotype Polarization to M1 via the Notch Signaling Pathway. Molecules. 2019;24:2016. doi: 10.3390/molecules24102016. PubMed DOI PMC

Ye Z.N., Yuan F., Liu J.Q., Peng X.R., An T., Li X., Kong L.M., Qiu M.H., Li Y. Physalis Peruviana-Derived 4beta-Hydroxywithanolide E, a Novel Antagonist of Wnt Signaling, Inhibits Colorectal Cancer In Vitro and In Vivo. Molecules. 2019;24:1146. doi: 10.3390/molecules24061146. PubMed DOI PMC

Luo Y., Ren Z., Du B., Xing S., Huang S., Li Y., Lei Z., Li D., Chen H., Huang Y., et al. Structure Identification of ViceninII Extracted from Dendrobium officinale and the Reversal of TGF-beta1-Induced Epithelial—Mesenchymal Transition in Lung Adenocarcinoma Cells through TGF-beta/Smad and PI3K/Akt/mTOR Signaling Pathways. Molecules. 2019;24:144. doi: 10.3390/molecules24010144. PubMed DOI PMC

Sperlich J., Teusch N. Pseudopterosin Inhibits Proliferation and 3D Invasion in Triple-Negative Breast Cancer by Agonizing Glucocorticoid Receptor Alpha. Molecules. 2018;23:1992. doi: 10.3390/molecules23081992. PubMed DOI PMC

Kim J.J., Kim K., Jung Y.R., Bian Y., Ngo T., Bae O.N., Lim K.M., Chung J.H. Co-Existence of Hypertensive and Anti-Hypertensive Constituents, Synephrine, and Nobiletin in Citrus unshiu Peel. Molecules. 2019;24:1197. doi: 10.3390/molecules24071197. PubMed DOI PMC

Shu C., Ge H., Song M., Chen J.H., Zhou H., Qi Q., Wang F., Ma X., Yang X., Zhang G., et al. Discovery of Imigliptin, a Novel Selective DPP-4 Inhibitor for the Treatment of Type 2 Diabetes. ACS Med. Chem. Lett. 2014;5:921–926. doi: 10.1021/ml5001905. PubMed DOI PMC

Safavi M., Foroumadi A., Abdollahi M. The Importance of Synthetic Drugs for Type 2 Diabetes Drug Discovery. Expert Opin. Drug Discov. 2013;8:1339–1363. doi: 10.1517/17460441.2013.837883. PubMed DOI

Yang S., Meng Y., Yan J., Wang N., Xue Z., Zhang H., Fan Y. Polysaccharide-Enriched Fraction from Amillariella Mellea Fruiting Body Improves Insulin Resistance. Molecules. 2018;24:46. doi: 10.3390/molecules24010046. PubMed DOI PMC

Elfawy H.A., Das B. Crosstalk between Mitochondrial Dysfunction, Oxidative Stress, and Age Related Neurodegenerative Disease: Etiologies and Therapeutic Strategies. Life Sci. 2019;218:165–184. doi: 10.1016/j.lfs.2018.12.029. PubMed DOI

Namsi A., Nury T., Khan A.S., Leprince J., Vaudry D., Caccia C., Leoni V., Atanasov A.G., Tonon M.C., Masmoudi-Kouki O., et al. Octadecaneuropeptide (ODN) Induces N2a Cells Differentiation through a PKA/PLC/PKC/MEK/ERK-Dependent Pathway: Incidence on Peroxisome, Mitochondria, and Lipid Profiles. Molecules. 2019;24:3310. doi: 10.3390/molecules24183310. PubMed DOI PMC

Feng X., McDonald J.M. Disorders of Bone Remodeling. Annu. Rev. Pathol. 2011;6:121–145. doi: 10.1146/annurev-pathol-011110-130203. PubMed DOI PMC

Khosla S., Hofbauer L.C. Osteoporosis Treatment: Recent Developments and Ongoing Challenges. Lancet Diabetes Endocrinol. 2017;5:898–907. doi: 10.1016/S2213-8587(17)30188-2. PubMed DOI PMC

Vuorinen A., Engeli R.T., Leugger S., Bachmann F., Akram M., Atanasov A.G., Waltenberger B., Temml V., Stuppner H., Krenn L., et al. Potential Antiosteoporotic Natural Product Lead Compounds That Inhibit 17beta-Hydroxysteroid Dehydrogenase Type 2. J. Nat. Prod. 2017;80:965–974. doi: 10.1021/acs.jnatprod.6b00950. PubMed DOI PMC

Zhang N.D., Han T., Huang B.K., Rahman K., Jiang Y.P., Xu H.T., Qin L.P., Xin H.L., Zhang Q.Y., Li Y.M. Traditional Chinese Medicine Formulas for the Treatment of Osteoporosis: Implication for Antiosteoporotic Drug Discovery. J. Ethnopharmacol. 2016;189:61–80. doi: 10.1016/j.jep.2016.05.025. PubMed DOI

Yodthong T., Kedjarune-Leggat U., Smythe C., Wititsuwannakul R., Pitakpornpreecha T. l-Quebrachitol Promotes the Proliferation, Differentiation, and Mineralization of MC3T3-E1 Cells: Involvement of the BMP-2/Runx2/MAPK/Wnt/beta-Catenin Signaling Pathway. Molecules. 2018;23:3086. doi: 10.3390/molecules23123086. PubMed DOI PMC

Fan Y.S., Li Q., Hamdan N., Bian Y.F., Zhuang S., Fan K., Liu Z.J. Tetrahydroxystilbene Glucoside Regulates Proliferation, Differentiation, and OPG/RANKL/M-CSF Expression in MC3T3-E1 Cells via the PI3K/Akt Pathway. Molecules. 2018;23:2306. doi: 10.3390/molecules23092306. PubMed DOI PMC

Duraipandiyan V., Al-Harbi N.A., Ignacimuthu S., Muthukumar C. Antimicrobial Activity of Sesquiterpene Lactones Isolated from Traditional Medicinal Plant, Costus Speciosus (Koen ex.Retz.) Sm. BMC Complement. Altern. Med. 2012;12:13. doi: 10.1186/1472-6882-12-13. PubMed DOI PMC

Xiao C.W., Liu Y., Wei Q., Ji Q.A., Li K., Pan L.J., Bao G.L. Inhibitory Effects of Berberine Hydrochloride on Trichophyton mentagrophytes and the Underlying Mechanisms. Molecules. 2019;24:742. doi: 10.3390/molecules24040742. PubMed DOI PMC

Malanik M., Treml J., Rjaskova V., Tizkova K., Kaucka P., Kokoska L., Kubatka P., Smejkal K. Maytenus Macrocarpa (Ruiz & Pav.) Briq.: Phytochemistry and Pharmacological Activity. Molecules. 2019;24:2288. PubMed PMC

Stanislawska I., Liwinska W., Lyp M., Stojek Z., Zabost E. Recent Advances in Degradable Hybrids of Biomolecules and NGs for Targeted Delivery. Molecules. 2019;24:1873. doi: 10.3390/molecules24101873. PubMed DOI PMC