Six-week inhalation of CdO nanoparticles in mice: The effects on immune response, oxidative stress, antioxidative defense, fibrotic response, and bones
Language English Country Great Britain, England Media print-electronic
Document type Journal Article
PubMed
31707033
DOI
10.1016/j.fct.2019.110954
PII: S0278-6915(19)30744-6
Knihovny.cz E-resources
- Keywords
- Cadmium oxide nanoparticles, Inhalation, Mice, Nanotoxicology,
- MeSH
- Administration, Inhalation MeSH
- Immunity, Cellular drug effects MeSH
- Cytokines metabolism MeSH
- Fibrosis chemically induced MeSH
- Metal Nanoparticles administration & dosage toxicity MeSH
- Kidney drug effects pathology MeSH
- Lymph Nodes drug effects MeSH
- Mice, Inbred ICR MeSH
- Oxidative Stress drug effects MeSH
- Oxides administration & dosage toxicity MeSH
- Spleen drug effects MeSH
- Cadmium Compounds administration & dosage toxicity MeSH
- Intestines drug effects MeSH
- Thymus Gland drug effects MeSH
- Tibia drug effects MeSH
- Animals MeSH
- Check Tag
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- cadmium oxide MeSH Browser
- Cytokines MeSH
- Oxides MeSH
- Cadmium Compounds MeSH
Due to the growing number of applications of cadmium oxide nanoparticles (CdO NPs), there is a concern about their potential deleterious effects. The objective of our study was to investigate the effect of CdO NPs on the immune response, renal and intestine oxidative stress, blood antioxidant defence, renal fibrotic response, bone density and mineral content. Six-week-old female ICR mice were exposed to CdO NPs for 6 weeks by inhalation (particle size: 9.82 nm, mass concentration: 31.7 μg CdO/m3, total deposited dose: 0.195 μg CdO/g body weight). CdO NPs increased percentage of thymus CD3e+CD8a+ cells and moderately enhanced splenocyte proliferation and production of cytokines and chemokines. CdO NPs elevated pro-fibrotic factors (TGF-β2, α-SMA and collagen I) in the kidney, and concentrations of AGEs in the intestine. The ratio of GSH and GSSG in blood was slightly reduced. Exposure to CdO NPs resulted in 10-fold higher Cd concentration in tibia bones. No differences were found in bone mass density, mineral content, bone area values, bone concentrations of Ca, P, Mg and Ca/P ratio. Our findings indicate stimulation of immune/inflammatory response, oxidative stress in the intestine, starting fibrotic response in kidneys and accumulation of CdO NPs in bones of mice.
Faculty of Medicine Slovak Medical University Limbova 12 83303 Bratislava Slovakia
Faculty of Public Health Slovak Medical University Limbova 12 83303 Bratislava Slovakia
Institute of Analytical Chemistry of Czech Academy of Sciences Veveri 97 60200 Brno Czech Republic
Norwegian Institute for Air Research Health Effects Laboratory PO Box 100 2027 Kjeller Norway
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