Combined use of galectin-3 and thyroid peroxidase improves the differential diagnosis of thyroid tumors
Language English Country Slovakia Media print-electronic
Document type Journal Article
PubMed
31777257
DOI
10.4149/neo_2019_190128n86
PII: 190128N86
Knihovny.cz E-resources
- MeSH
- Autoantigens genetics MeSH
- Diagnosis, Differential MeSH
- Galectin 3 genetics MeSH
- Galectins MeSH
- Iodide Peroxidase genetics MeSH
- Blood Proteins MeSH
- Humans MeSH
- Biomarkers, Tumor genetics MeSH
- Thyroid Neoplasms classification diagnosis MeSH
- Iron-Binding Proteins genetics MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Autoantigens MeSH
- Galectin 3 MeSH
- Galectins MeSH
- Iodide Peroxidase MeSH
- Blood Proteins MeSH
- LGALS3 protein, human MeSH Browser
- Biomarkers, Tumor MeSH
- Iron-Binding Proteins MeSH
- TPO protein, human MeSH Browser
The differential diagnosis of well-differentiated tumors of follicular cell origin remains the most problematic task in thyroid pathology. Specific morphologic criteria (capsular and/or vascular invasion, nuclear characteristics) are crucial in the diagnosis of these neoplasms. However, the assessment of malignant features is inconclusive in some cases. Moreover, oncocytic thyroid tumors remain controversial in a respect to their pathobiology, behavior and management. Therefore, the useful diagnostic/prognostic thyroid markers are awaited. The aim of our study was to evaluate the expression of galectin-3 and thyroid peroxidase (TPO) in benign and malignant thyroid tumors of follicular cell origin. A total of 186 archival thyroid samples including 38 non-oncocytic follicular adenomas, 53 oncocytic (Hürthle cell) adenomas, 6 non-oncocytic follicular carcinomas, 23 oncocytic (Hürthle cell) carcinomas, 43 non-oncocytic papillary carcinomas, and 23 oncocytic papillary carcinomas were analyzed for galectin-3 and TPO expression by immunohistochemistry. Both types of papillary carcinomas showed significant upregulation of galectin-3 in comparison with the other tumor types, likewise, significant differences in galectin-3 expression were discovered between non-oncocytic and oncocytic variants of studied tumors excluding follicular carcinoma. Significant lowering of TPO was revealed in oncocytic adenomas and papillary carcinomas. In conclusion, the combined use of galectin-3 and TPO markers could help to improve the differential diagnosis of thyroid tumors. Differences in the galectin-3 and TPO expression between some oncocytic and non-oncocytic tumors support their separation in the latest WHO classification of thyroid tumors.
References provided by Crossref.org
Follicular Epithelial Dysplasia as Hashimoto Thyroiditis-Related Atypia: a Series of 91 Specimens
