Linezolid-induced lactic acidosis - a brief overview with a case report
Klinicka mikrobiologie a infekcni lekarstvi.
2019 Sep ;
25 (3) :
92-96.
Language Czech Country Czech Republic Media print
Document type Case Reports, Journal Article, Review
Persistent link
https://www.medvik.cz/link/pmid31904104
PubMed
31904104
- MeSH
- Acidosis, Lactic * diagnosis etiology pathology MeSH
- Anti-Bacterial Agents adverse effects therapeutic use MeSH
- Humans MeSH
- Linezolid adverse effects MeSH
- Osteomyelitis * complications drug therapy etiology MeSH
- Oxazolidinones * MeSH
- Aged MeSH
- Sepsis * etiology MeSH
- Staphylococcal Infections * complications drug therapy etiology MeSH
- Treatment Outcome MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Aged MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Review MeSH
- Names of Substances
- Anti-Bacterial Agents MeSH
- Linezolid MeSH
- Oxazolidinones * MeSH
Lactic acidosis is a rare but serious adverse event linked to treatment with linezolid, an oxazolidinone antibiotic. Presented is a case of a 67-year-old man treated for 26 days with linezolid for staphylococcal osteomyelitis of the right foot with subsequent sepsis. During the course of treatment, severe lactic acidosis developed, requiring hospitalization in an intensive care unit. The likely mechanism of this potentially life-threatening complication is discussed.
