Use of autologous platelet-rich plasma in healing skin graft donor sites
Jazyk angličtina Země Velká Británie, Anglie Médium print
Typ dokumentu časopisecké články, randomizované kontrolované studie
- Klíčová slova
- growth factors, platelet-rich plasma, thrombocytes, wound healing,
- MeSH
- autologní krevní transfuze MeSH
- časové faktory MeSH
- dospělí MeSH
- emoliencia aplikace a dávkování MeSH
- hojení ran * fyziologie MeSH
- kůže patofyziologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- místo odběru štěpu * patofyziologie MeSH
- mladiství MeSH
- mladý dospělý MeSH
- obvazy MeSH
- plazma bohatá na destičky * fyziologie MeSH
- prospektivní studie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- stehno MeSH
- transplantace kůže * MeSH
- vazelína aplikace a dávkování MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- randomizované kontrolované studie MeSH
- Názvy látek
- emoliencia MeSH
- vazelína MeSH
OBJECTIVE: To demonstrate that the use of platelet-rich plasma (PRP) enhances both the quality of healing and the time required for wound healing at a skin graft donor site. METHODS: Patients who had dermo-epidermal skin grafts taken from the thigh area were included in a prospective, randomised clinical study. PRP was applied to one donor site and then covered with Vaseline-impregnated, open-weave gauze and gauze, while the contralateral donor site on the other thigh served as a control and was covered with the open-weave gauze and gauze without PRP. RESULTS: A total of 24 patients took part in the study, of which three developed infections and were thus removed from the study. Use of PRP reduced the wound healing time of the dermo-epidermal graft donor sites by a mean 17.8% and median 18 days. On average, the treated donor sites healed in 14.9 days compared with 18.4 days for the control group. The median was 14 days compared with 18 days in the control group (p=0.026). In one patient, healing was slower on the side where PRP was applied. In 20 patients, healing of the donor site was accelerated where PRP was applied. CONCLUSION: The study demonstrated a beneficial effect of PRP, as healing time was shortened. Using PRP to heal wounds could be beneficial for patients for whom commonly available wound healing therapies have failed, as well as for high-risk patient groups for whom problematic wound healing may be expected.
Citace poskytuje Crossref.org
