Drug-induced Hemolysis in G6PD Deficiency: an Unusual Presentation of a Common Clinical Condition
Language English Country Czech Republic Media print
Document type Case Reports, Journal Article
PubMed
32036850
DOI
10.14712/18059694.2020.7
PII: am_2019062040166
Knihovny.cz E-resources
- Keywords
- G6PD deficiency, hydralazine, intravascular hemolysis, isosorbide dinitrate,
- MeSH
- Drug Combinations MeSH
- Hemolysis drug effects MeSH
- Hydralazine adverse effects MeSH
- Isosorbide Dinitrate adverse effects MeSH
- Cardiovascular Agents adverse effects MeSH
- Middle Aged MeSH
- Humans MeSH
- Glucosephosphate Dehydrogenase Deficiency chemically induced diagnosis MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Names of Substances
- Drug Combinations MeSH
- Hydralazine MeSH
- Isosorbide Dinitrate MeSH
- isosorbide-hydralazine combination MeSH Browser
- Cardiovascular Agents MeSH
Glucose-6-phosphate dehydrogenase (G6PD) deficiency can present a diagnostic dilemma owing to the varying degrees of disease severity and the wide range of precipitating factors. Here, we report a case of a 56-year-old man who presented with signs and symptoms of heart failure and, during the course of treatment, developed intravascular hemolysis. On investigation, he was found to be G6PD deficient. Following discontinuation of the fixed-dose combination of isosorbide dinitrate and hydralazine, the clinical condition of the patient improved, and there were no further episodes of hemolysis. The case highlights the need for a high degree of suspicion of G6PD deficiency in patients with unexplained signs and symptoms of intravascular hemolysis.
References provided by Crossref.org
