MPI_AGE is a European Union co-funded research project aimed to use the Multidimensional Prognostic Index (MPI), a validated Comprehensive Geriatric Assessment (CGA)-based prognostic tool, to develop predictive rules that guide clinical and management decisions in older people in different European countries. A series of international studies performed in different settings have shown that the MPI is useful to predict mortality and risk of hospitalization in community-dwelling older subjects at population level. Furthermore, studies performed in older people who underwent a CGA before admission to a nursing home or receiving homecare services showed that the MPI successfully identified groups of persons who could benefit, in terms of reduced mortality, of specific therapies such as statins in diabetes mellitus and coronary artery disease, anticoagulants in atrial fibrillation and antidementia drugs in cognitive decline. A prospective trial carried out in nine hospitals in Europe and Australia demonstrated that the MPI was able to predict not only in-hospital and long-term mortality, but also institutionalization, re-hospitalization and receiving homecare services during the one-year follow-up after hospital discharge. The project also explored the association between MPI and mortality in hospitalized older patients in need of complex procedures such as transcatheter aortic valve implantation or enteral tube feeding. Evidence from these studies has prompted the MPI_AGE Investigators to formulate recommendations for healthcare providers, policy makers and the general population which may help to improve the cost-effectiveness of appropriate health care interventions for older patients.

1st Faculty of Medicine Charles University Prague Czech Republic

Ageing Clinical Research Dpt 2 of Internal Medicine and Center of Molecular Medicine University of Cologne Medical Faculty Cologne Germany

Aging Research Center Department of Neurobiology Care Sciences and Society Karolinska Institutet and Stockholm University Stockholm Sweden

Aging Section National Research Council Padua Italy

Department of Clinical Pharmacology College of Medicine and Public Health Flinders Medical Centre Flinders University Adelaide Australia

Department of Geriatric Care Orthogeriatrics and Rehabilitation E O Galliera Hospital Mura delle Cappuccine 14 16128 Genoa Italy

Department of Interdisciplinary Medicine University of Bari Bari Italy

Erasmus University Medical Center Rotterdam The Netherlands

Geriatrics Department University Hospital Poitiers and Centre Investigation Clinique 1402 University of Poitiers CHU Poitiers INSERM Poitiers France

Geriatrics Unit San Antonio Hospital Padua Italy

National Institute on Aging Baltimore MD USA

Servicio de Geriatría Hospital Universitario Ramón y Cajal Madrid Spain

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