A gluten-free diet is a special type of diet intended for people with celiac disease. The objective of this article is to report the past, present production, supply of gluten-free products as well as their future position in our market. In the past, there were only limited gluten-free products available and the awareness of the diet was limited to paediatric community. There were only few raw gluten-free materials and almost all the production was created in households. Later with the introduction of targeted screening into the practice, celiac diagnosis has improved, with an increase in newly diagnosed patients who have remained life-long dependents on a gluten-free diet. This was associated with an increased production of gluten-free products, referred to as weight loss diet, with their positive effects on health. Subsequently, the gluten-free diet has also been voluntarily adopted by both people with other diseases and healthy individuals. In the future, the gluten-free diet consumption is expected to increase, due to its increased popularity in populations. In this regard, gluten-free diets have been misinterpreted as a "miracle drug" that is effective on a variety of problems. The medical community will be confronting the future problems of people who are dependent on a gluten-free diet as well as the complications arising from the consumers of a gluten-free diet for no medical reasons. Compliance to the principles of a gluten-free diet should be maintained and should not be recommended to healthy individuals or those without relevant reasons.

Clinical Emergency Pediatric Hospital Clinic of Pediatrics 2 Iuliu Hațieganu Iuliu Hatieganu University of Medicine and Pharmacy Crisan Street 3 5 No 400177 Cluj Napoca Romania

Czech Centre for Phenogenomics Division BIOCEV Prumyslova 595 252 50 Vestec Czech Republic

Department of Biology Faculty of Education Selye Janos University Bratislavska 3322 Komarno Slovak Republic

Department of Cell Biology Faculty of Science Charles University Prague Albertov 6 128 00 Prague 2 Czech Republic

Department of Public Health and Hygiene Faculty of Medicine Pavol Jozef Safarik University in Kosice Trieda SNP 1 040 11 Kosice Slovak Republic

Laboratory of Immunotherapy Institute of Microbiology AS CR v v i Videnska 1083 142 20 Prague 4 Czech Republic

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Collin P, Thorell L, Kaukinen K, Maki M. The safe threshold for gluten contaminantion in gluten-free product Can trace amounts be accepted in the treatment of coeliac disease? Aliment Pharmacol Ther. 2014;12:1277–83. PubMed

Azani M, Badfar G, Abangah G, Mahmoudi L. Celiac disease in Iranian irritable bowel syndrome patients; a systematic review and meta-analysis. Gastroenterol Hepatol Bed Bench. 2019;12:85–97. PubMed PMC

Yoosuf S, Makharia GK. Evolving therapy for Celiac disease. Front Pediatr. 2019;7:193. PubMed PMC

Catassi C, Ratsch IM, Fabiani E, Rossini M, Bordicchia F, Candela F, Coppa GV, Giorgi PL. Coeliac disease in the year 2000: exploring the iceberg. Lancet. 1994;343:200–3. PubMed

Samasca G, Lerner A, Girbovan A, Sur G, Lupan I, Makovicky P, et al. Challenges in gluten-free diet in coeliac disease: Prague consensus. Eur J Clin Invest. 2017;47:394–7. PubMed

Gee SJ. S. Bartholomews Hospital Reports. 1888;35:321.

Dicke WK. Coeliac disease. Investigation of the harmful effects of certain types of cereal on patients with coelaic disease (Thesis) The Netherlands: University of Utrecht; 1950.

Makovicky P, Makovicky P, Jilek F. From historical data and opinions to present challenges in the field of celiac disease. Epidemiol Mikrobiol Imunol. 2008;57:90–6. PubMed

Bold J, Rostami K. Gluten tolerance; potential challenges in treatment strategies. Gastroenterol Hepatol Bed Bench. 2011;4:53–7. PubMed PMC

Collin P, Vilppula A, Luostarinen L, Holmes GKT, Kaukinen K. Review article: coeliac disease in later life must not be missed. Aliment Pharmacol Ther. 2018;5:563–72. PubMed

Catassi C, Fabiani E, Lacono G, Dagate C, Francavilla R, Biagi F, et al. A prospective, double-blind, placebo-controlled trial to establish a safe gluten threshold for patients with celiac disease. Am J Clin Nutr. 2007;85:160–6. PubMed

Ciclitira PJ, Ellis HJ, Lundin KE. Gluten-free diet – what is toxic? Best Pract Res Clin Gastroenterol. 2005;19:359–71. PubMed

Cohen IS, Day AS, Shaoul R. Gluten in Celiac disease–More or less? Rambam Maimonides Med J. 2019;10:1–6. PubMed PMC

Hischenhuber C, Crevel R, Jarry B, Maki M, Moneret-Vautrin DA, Romano A, et al. Review article: safe amounts of gluten for patients with wheat allergy or coeliac disease. Aliment Pharmacol Ther. 2006;23:559–75. PubMed

Lahdeaho ML, Maki M, Laurila K, Huhtala H, Kaukinen K. Small-bowel mucosal changes and antibody responses after low- and moderate-dose gluten challenge in celiac disease. BMC Gastroenterol. 2011;11:129. PubMed PMC

Makovicky P, Makovicky P, Lupan I, Samasca G, Sur G, Freeman HJ. Perspective: Gluten-free product for patients with celiac disease should not contain trace levels. Adv Nutr. 2017;8:409–11. PubMed PMC

Makovicky P, Samasca G, Freeman HJ, Makovicky P. Gluten-free diet in a law trap: how long will celiac patients wait to see a change of the legislation? Rev Posud Lek. 2017;20:65–73.

Samasca G. A dialogue with Professor Michael N. Marsh. Int J Celiac Dis. 2016;4:34–7.

Makovicky P. A dialogue with Professor Hugh Freeman. Int J Celiac Dis. 2016;4:105–8.

Samasca G. A dialogue with Professor Aaron Lerner. Int J Celiac Dis. 2016;4:109–12.

Makovicky P. A dialogue with Dr. Mohammad Rostami Nejad. Int J Celiac Dis. 2017;5:83–5.

Samasca G. A dialogue with Professor Andras Arato. Int J Celiac Dis. 2019;7:58–62.

Makovicky P. A dialogue with Assistant professor Hakim Rahmoune. Int J Celiac Dis. 2019;7:63–5.

Perlmutter D. Brain marker: The power of gut microbes to heal and protect your brain for life hardcover. Hodder & Stoughton Ltd: London. 2015:310.

Davis W. Wheat belly: Lose the wheat, lose the weight, and find your path back to health. New York: Rodale. 2014

Djokovic N, Davis W. Serve to win. New York: Random house publishing group. 2013

Editorial Gluten: going against the grain? Lancet Gastroenterol Hepatol. 2016;1:85. PubMed

Laszkowska M, Shiwani H, Belluz J, Ludvigsson JF, Green PHR, Sheenan D, et al. Socioeconomic vs health-related factors associated with google searches for gluten-free diet. Clin Gastroenterol Hepatol. 2017;16:295–7. PubMed

Harper L, Bold J. An exploration into the motivation for gluten avoidance in the absence of coeliac disease. Gastroenterol Hepatol Bed Bench. 2018;11:259–68. PubMed PMC

Kim HS, Demyen MF, Mathew J, Kothari N, Feurdean M, Ahlawat SK. Obesity, metabolic syndrome, and cardiovascular risk in gluten-free followers without celiac disease in the United States from the National Health and Nutrition Examination Survey 2009-2014. Dig Dis Sci. 2017;9:2440–8. PubMed

Perrin L, Alles B, Buscail C, Ravel C, Hercberh S, Julia C, et al. Gluten-free diet in French adults without coeliac disease: sociodemographic characteristics, motives and dietary profile. Br J Nutr. 28;122:231–9. PubMed

Makovicky P, Chrenkova M, Makovicky P, Flak P, Formelova Z, Novosadova V, et al. The effect of selected feed mixtures on the duodenal morphology. Physiol Res. 2018;67:955–62. PubMed

Mariani P, Viti MG, Montuori M, La Vecchia A, Cipolletta E, Calvani L, et al. The gluten-free diet: a nutritional risk factor for adolescent with celiac disease? J Pediatr Gastroeneterol Nutr. 1998;5:519–23. PubMed

Potter MDE, Brienesse SC, Walker MM, Bolyle A, Talley NJ. Effect of the gluten-free diet on cardiovascular risk factors in patients with coeliac disease: A systematic review. J Gastroenterol Hepatol. 2018;4:781–91. PubMed

Raehsler SL, Choung RS, Marietta EV, Murray JA. Accumulation of heavy metals in people on a gluten-free diet. Clin Gastroenterol Hepatol. 2018;2:244–51. PubMed

Rostami K, Aldulaimi D, Rostami-Nejad M. Gluten free diet is a cure not a poison! Gastroenterol Hepatol Bed Bench. 2015;8:93–4. PubMed PMC

Naland B, Cash BD. Health benefits and adverse effects of a gluten-free diet in non-celiac disease patients. Gastroenterol Hepatol. 2018;2:82–91. PubMed PMC

Freeman HJ. Adverse effects of gluten-free diet. Int J Celiac Dis. 2018;6:71–3.

Ciofii I, Santarpia L, Vaccaro A, Naccarato M, Iacone R, Marra M, et al. Subjective palatability and appetite after gluten-free pasta: A pilot study. Acta Aliment . 2019:1–9.

Samasca G, Sur G, Lupan I, Deleanu D. Gluten-free diet and quality of life in celiac disease. Gastroenterol Hepatol Bed Bench. 2014;7:139–43. PubMed PMC

Lerner A, Shoenfeld Y, Matthias T. Adverse effects of gluten ingestion and advantages of gluten withdrawal in nonceliac autoimmune disease. Nutr Rev. 2017;12:1046–58. PubMed

Lerner A, Ramesh A, Matthias T. Are non-celiac autoimmune diseases responsive to gluten-free diet? Int J Celiac Dis . 2017;5:164–7.

Haupt-Jorgensen M, Holm LJ, Josefsen K, Buschard K. Possible prevention of diabetes with a gluten-free diet. Nutrients. 2018;11:E1746. PubMed PMC

Talaie R. Does gluten free diet have more implications than treatment of celiac disease? Gastroenterol Hepatol Bed Bench. 2015;8:160–6. PubMed PMC

Rostami-Nejad M, Sadeghi A, Asadzadeh-Aghdaei H, Rismantab S, Reza Zali M. Gluten-free diet for refractory inflammatory bowel disease; a case report. Int J Celiac Dis. 2017;5:168–70.

Pastore MR, Bazzigaluppi E, Belloni C, Arcovio C, Bonifacio E, Bosi E. Six mounts of gluten-free diet do not influence autoantibody titters, but improve insulin secretion in subject at high risk for type 1 diabetes. J Clin Endocrinol Metabol. 2003;88:162–5. PubMed

Casella G, Pozzi R, Gigognetti M, Bachetti F, Torti G, Cadei M, et al. Mood disorders and non-celiac gluten sensitivity. Minerva Gastroenterol Dietol. 2017;63:32–7. PubMed

Jackson JR, Eaton WW, Cascella NG, Fasano A, Kelly DL. Neurologic and psychiatric manifestations of celiac disease and gluten sensitivity. Psychiatr Q. 2012;1:91–102. PubMed PMC

Levinta A, Mukovozov I, Tsoutsoulas C. Use of a gluten-free diet in schizophrenia: A systematic review. Adv Nutr. 2018;9:824–32. PubMed PMC

Caio G, Volta U, Sapone A, Leffler DA, De Giorgio R, Catassi C, et al. Celiac disease: a comprehensive current review. BMC Med. 2019;17 PubMed PMC