Patient perception of anticoagulant treatment for stroke prevention (RE-SONANCE study)
Language English Country England, Great Britain Media electronic-ecollection
Document type Journal Article, Multicenter Study, Observational Study, Research Support, Non-U.S. Gov't
PubMed
32257246
PubMed Central
PMC7103803
DOI
10.1136/openhrt-2019-001202
PII: openhrt-2019-001202
Knihovny.cz E-resources
- Keywords
- atrial fibrillation, quality of care and outcomes, stroke,
- MeSH
- Anticoagulants administration & dosage adverse effects MeSH
- Antithrombins administration & dosage adverse effects MeSH
- Administration, Oral MeSH
- Time Factors MeSH
- Stroke diagnosis etiology prevention & control MeSH
- Dabigatran administration & dosage adverse effects MeSH
- Adult MeSH
- Atrial Fibrillation complications diagnosis drug therapy MeSH
- Hemorrhage chemically induced MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Drug Substitution MeSH
- Protective Factors MeSH
- Prospective Studies MeSH
- Risk Factors MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Patient Satisfaction * MeSH
- Vitamin K antagonists & inhibitors MeSH
- Treatment Outcome MeSH
- Health Knowledge, Attitudes, Practice * MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Multicenter Study MeSH
- Observational Study MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Europe MeSH
- Israel MeSH
- Names of Substances
- Anticoagulants MeSH
- Antithrombins MeSH
- Dabigatran MeSH
- Vitamin K MeSH
OBJECTIVE: We evaluated atrial fibrillation (AF) patients' perceptions of anticoagulation treatment with dabigatran or a vitamin K antagonist (VKA) for stroke prevention, according to accepted indications. METHODS: The RE-SONANCE observational, prospective, multicentre, international study used the validated Perception on Anticoagulant Treatment Questionnaire (PACT-Q) to assess patients with AF already taking a VKA who were switched to dabigatran (cohort A), and newly diagnosed patients initiated on either dabigatran or a VKA (cohort B). Visit 1 (V1) was at baseline, and visit 2 (V2) and visit 3 (V3) were at 30-45 and 150-210 days after baseline, respectively. Primary outcomes were treatment satisfaction and convenience in cohort A at V2 and V3 versus baseline, and in cohort B for dabigatran and a VKA at V2 and V3. RESULTS: The main analysis set comprised 4100 patients in cohort A and 5365 in cohort B (dabigatran: 3179; VKA: 2186). In cohort A, PACT-Q2 improved significantly (p<0.001 for all) for treatment convenience (mean change V1 vs V2=20.72; SD=21.50; V1 vs V3=24.54; SD=22.85) and treatment satisfaction (mean change V1 vs V2=17.60; SD=18.76; V1 vs V3=21.04; SD=20.24). In cohort B, mean PACT-Q2 scores at V2 and V3 were significantly higher (p<0.001 for all) for dabigatran versus a VKA for treatment convenience (V2=18.38; SE =0.51; V3=23.34; SE=0.51) and satisfaction (V2=15.88; SE=0.39; V3=19.01; SE=0.41). CONCLUSIONS: Switching to dabigatran from long-term VKA therapy or newly initiated dabigatran is associated with improved patient treatment convenience and satisfaction compared with VKA therapy.
1st Department of Cardiology Silesian Medical University Katowice Poland
1st Department of Internal Medicine Tolna County 'Balassa Janos' Teaching Hospital Szekszard Hungary
Biostatistics and Data Sciences Boehringer Ingelheim Pharmaceuticals Inc Ridgefield Connecticut USA
Boehringer Ingelheim RCV GmbH and Co KG Vienna Austria
Cardiology Department Riga Stradins University Riga Latvia
Cardiology University and Emergency Hospital of Bucharest Bucharest Other Romania
Clalit Health Services Bonen Clinic Haifa Israel
Department of Cardiology Clinical Centre of Serbia Belgrade Serbia
Department of Cardiology General Hospital Celje Celje Slovenia
Department of Cardiology National Cardiology Hospital Sofia Bulgaria
Department of Cardiology North Estonia Medical Centre Foundation Tallinn Estonia
Faculty of Medicine in Hradec Kralové Charles University Broumov Czech Republic
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