Heterogenous mutation spectrum and deregulated cellular pathways in aberrant plasma cells underline molecular pathology of light-chain amyloidosis
Language English Country Italy Media electronic
Document type Letter, Research Support, Non-U.S. Gov't
PubMed
32381580
PubMed Central
PMC7849586
DOI
10.3324/haematol.2019.239756
PII: haematol.2019.239756
Knihovny.cz E-resources
- MeSH
- Amyloidosis * diagnosis genetics MeSH
- Immunoglobulin Light Chains genetics MeSH
- Humans MeSH
- Pathology, Molecular MeSH
- Mutation MeSH
- Plasma Cells MeSH
- Immunoglobulin Light-chain Amyloidosis * diagnosis genetics MeSH
- Check Tag
- Humans MeSH
- Publication type
- Letter MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Immunoglobulin Light Chains MeSH
Biosciences Institute Newcastle University Newcastle upon Tyne United Kingdom
Brno University of Technology Centre of Excellence IT4Innovations Brno Czech Republic
Charles University Hospital Pilsen Czech Republic
Dana Farber Cancer Institute Harvard Medical School Boston MA USA
Department of Biology and Ecology Faculty of Science University of Ostrava Czech Republic
Department of Haematology and Transfusiology University Hospital Bratislava Slovakia
Department of Haematology Medical University of Lodz Copernicus Memorial Hospital Łódź Poland
Department of Haematology Oncology and Internal Diseases Medical University of Warsaw Poland
Department of Haematooncology University Hospital Ostrava Ostrava Czech Republic
Department of Internal Medicine Hematology and Oncology University Hospital Brno Czech Republic
Dept and Clinic of Haematology Blood Neoplasms Wroclaw Medical University Poland
Dept of Haematology and Stem Cell Transplantation South Pest Central Hospital Budapest Hungary
Dept of Hematology and Cancer Prevention Medical University of Silesia in Katowice Poland
Dpt of Clinical studies Faculty of Medicine University of Ostrava Ostrava Czech Republic
Dpt of Medicine Multiple Myeloma Research Perlmutter Cancer Center NYU School of Medicine USA
Institute of Biostatistics and Analyses Masaryk University Brno Czech Republic
Institute of Molecular and Translational Medicine Palacky University Olomouc Czech Republic
IT4Innovations VSB Technical University of Ostrava Ostrava Czech Republic
Jagiellonian University Medical College Cracow Poland
RECETOX Faculty of Science Masaryk university in Brno Brno Czech Republic
See more in PubMed
Merlini G, Palladini G. Light chain amyloidosis: the heart of the problem. Haematologica. 2013;98(10):1492-1495. PubMed PMC
Desikan KR, Dhodapkar MV, Hough A, et al. Incidence and impact of light chain associated (AL) amyloidosis on the prognosis of patients with multiple myeloma treated with autologous transplantation. Leuk Lymphoma. 1997;27(3–4):315-319. PubMed
Jelinek T, Kryukova E, Kufova Z, Kryukov F, Hajek R. Proteasome inhibitors in AL amyloidosis: focus on mechanism of action and clinical activity. Hematol Oncol. 2017;35(4):408-419. PubMed
Jelinek T, Kufova Z, Hajek R. Immunomodulatory drugs in AL amyloidosis. Crit Rev Oncol Hematol. 2016;99:249-260. PubMed
Babayan A, Alawi M, Gormley M, et al. Comparative study of whole genome amplification and next generation sequencing performance of single cancer cells. Oncotarget. 2016;8(34):56066-56080. PubMed PMC
Itan Y, Shang L, Boisson B, Patin E, et al. The human gene damage index as a gene-level approach to prioritizing exome variants. Proc Natl Acad Sci U S A. 2015;112(44):13615-13620. PubMed PMC
Bolli N, Biancon G, Moarii M, et al. Analysis of the genomic landscape of multiple myeloma highlights novel prognostic markers and disease subgroups. Leukemia. 2018;32(12):2604-2616. PubMed PMC
Boyle EM, Ashby C, Wardell CP, et al. The genomic landscape of plasma cells in systemic light chain amyloidosis. Blood. 2018; 132(26):2775-2777. PubMed
Paiva B, Martinez-Lopez J, Corchete LA, et al. Phenotypic, transcriptomic, and genomic features of clonal plasma cells in light-chain amyloidosis. Blood. 2016;127(24):3035-3039. PubMed
Walker BA, Boyle EM, Wardell CP, et al. Mutational spectrum, copy number changes, and outcome: results of a sequencing study of patients with newly diagnosed myeloma. J Clin Oncol. 2015; 33(33):3911-3920. PubMed PMC
Kryukov F, Kryukova E, Brozova L, et al. Does AL amyloidosis have a unique genomic profile? Gene expression profiling meta-analysis and literature overview. Gene. 2016;591(2):490-498. PubMed
Crawford DR, Wang Y, Schools GP, Kochheiser J, Davies KJ. Downregulation of mammalian mitochondrial RNAs during oxidative stress. Free Radic Biol Med. 1997;1;22(3):551-559. PubMed
Oliva L, Orfanelli U, Resnati M, et al. The amyloidogenic light chain is a stressor that sensitizes plasma cells to proteasome inhibitor toxicity. Blood. 2017;129(15):2132-2142. PubMed
Bochtler T, Merz M, Hielscher T, et al. Cytogenetic intraclonal heterogeneity of plasma cell dyscrasia in AL amyloidosis as compared with multiple myeloma. Blood Adv. 2018;2(20):2607-2618. PubMed PMC