A sulphonamidic moiety was utilized as an electron-withdrawing group for enhancement of anion complexation features of urea-based receptors. A series of receptors varying in acidity of sulphonamidic and urea NH groups was synthesized and thoroughly tested. The individual complexation properties reflect deprotonation/complexation equilibrium in a given molecule as a function of the substitution. The receptors containing electron-donating groups in conjugation to the sulphonamidic moiety showed higher association constants towards H2 PO4- and carboxylate anions, while those containing electron-withdrawing groups inclined to deprotonation of sulphonamidic NH. The deprotonation issue can be avoided by alkylation at the early step of receptor synthesis or it can be utilized for insertion of suitable groups that enable its anchoring on various substrates to form more elaborated receptor structures.

Department of Analytical Chemistry Institute of Chemical Process Fundamentals of CAS v v i Rozvojová 135 Prague 6 16502 Czech Republic

Department of Inorganic Chemistry Faculty of Sciences Charles University Albertov 6 2030 Prague 2 12800 Czech Republic Czech Republic

Department of Molecular Electrochemistry and Catalysis J Heyrovský Institute of Physical Chemistry of CAS v v i Dolejškova 3 Prague 8 18223 Czech Republic

Department of Physical Chemistry University of Chemistry and Technology Prague Technická 5 Prague 6 16628 Czech Republic

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