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Level of Clonal Plasma Cells in Hematopoietic Cell Autografts Reflects the Pre-Transplant Bone Marrow Minimal Residual Disease in Multiple Myeloma Patients

. 2025 Apr ; 100 (4) : 704-707. [epub] 20250115

Status In-Process Language English Country United States Media print-electronic

Document type Letter

Grant support
CZ.10.03.01/00/22_003/0000003 European Union project LERCO
CZ.02.01.01/00/22_008/0004644 OP JAK SALVAGE, co-financed from the EU and the State budget
NU23-03-00374 Czech Health Research Council
MH CZ- DRO-FNOs/2022 Institutional support, University Hospital Ostrava
MH CZ-DRO- FNOs/2023 Institutional support, University Hospital Ostrava
MH CZ-DRO- FNOs/2024 Institutional support, University Hospital Ostrava
1/OR-FNO/2024 Institutional support, University Hospital Ostrava
e-INFRA CZ (ID:90254) Ministry of Education, Youth and Sports of the Czech Republic

See more in PubMed

Vogel W., Kopp H. G., Kanz L., and Einsele H., “Myeloma Cell Contamination of Peripheral Blood Stem‐Cell Grafts Can Predict the Outcome in Multiple Myeloma Patients After High‐Dose Chemotherapy and Autologous Stem‐Cell Transplantation,” Journal of Cancer Research and Clinical Oncology 131, no. 4 (2005): 214–218. PubMed

Kopp H. G., Yildirim S., Weisel K. C., Kanz L., and Vogel W., “Contamination of Autologous Peripheral Blood Progenitor Cell Grafts Predicts Overall Survival After High‐Dose Chemotherapy in Multiple Myeloma,” Journal of Cancer Research and Clinical Oncology 135, no. 4 (2009): 637–642. PubMed

Pasvolsky O., Milton D. R., Rauf M., et al., “Impact of Clonal Plasma Cells in Autografts on Outcomes in High‐Risk Multiple Myeloma Patients,” Blood Cancer Journal 13, no. 1 (2023): 68. PubMed PMC

Kostopoulos I. V., Eleutherakis‐Papaiakovou E., Rousakis P., et al., “Aberrant Plasma Cell Contamination of Peripheral Blood Stem Cell Autografts, Assessed by Next‐Generation Flow Cytometry, Is a Negative Predictor for Deep Response Post Autologous Transplantation in Multiple Myeloma; A Prospective Study in 199 Patients,” Cancers 13, no. 16 (2021): 4047. PubMed PMC

Urushihara R., Takezako N., Yoroidaka T., et al., “Eight‐Color Multiparameter Flow Cytometry (EuroFlow‐NGF) is as Sensitive as Next‐Generation Sequencing in Detecting Minimal/Measurable Residual Disease in Autografts of Patients With Multiple Myeloma,” EJHaem 4, no. 1 (2023): 184–191. PubMed PMC

Sonneveld P., Dimopoulos M. A., Boccadoro M., et al., “Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone for Multiple Myeloma,” New England Journal of Medicine 390, no. 4 (2024): 301–313. PubMed

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