Silver nanoparticles (AgNPs) have recently become very attractive for the scientific community due to their broad spectrum of applications in the biomedical field. The main advantages of AgNPs include a simple method of synthesis, a simple way to change their morphology and high surface area to volume ratio. Much research has been carried out over the years to evaluate their possible effectivity against microbial organisms. The most important factors which influence the effectivity of AgNPs against microorganisms are the method of their preparation and the type of application. When incorporated into fabric wound dressings and other textiles, AgNPs have shown significant antibacterial activity against both Gram-positive and Gram-negative bacteria and inhibited biofilm formation. In this review, the different routes of synthesizing AgNPs with controlled size and geometry including chemical, green, irradiation and thermal synthesis, as well as the different types of application of AgNPs for wound dressings such as membrane immobilization, topical application, preparation of nanofibers and hydrogels, and the mechanism behind their antimicrobial activity, have been discussed elaborately.

Department of Biochemistry Faculty of Science Masaryk University Kamenice 753 5 625 00 Brno Bohunice Czech Republic

Department of Biomedical and Environmental Analyses Faculty of Pharmacy Wroclaw Medical University Borowska 211 50 556 Wroclaw Poland

Department of Molecular Pharmacy Faculty of Pharmacy Masaryk University Palackeho 1946 1 612 00 Brno Czech Republic

Department of Pharmacology and Toxicology Faculty of Pharmacy Masaryk University Palackeho 1946 1 612 00 Brno Czech Republic

Department of Pharmacy School of Chemical and Biotechnology SASTRA Deemed University Thanjavur 613 401 India

Department of Research and Development Prevention Medicals Tovarni 342 742 13 Studenka Butovice Czech Republic

Department of Viticulture and Enology Faculty of Horticulture Mendel University in Brno Valticka 337 691 44 Lednice Czech Republic

Division of Environment and Sustainability Hong Kong University of Science and Technology Room 4412 Clear Water Bay Kowloon Hong Kong

Research Center for Environmental Monitoring and Modeling University of Science Vietnam National University 334 Nguyen Trai Street Hanoi 100000 Vietnam

School of Pharmacy and Life Sciences Robert Gordon University Garthdee Road Aberdeen AB10 7QB UK

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Marine Biomaterials: Hyaluronan

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