Polysaccharide nanoparticles are promising materials in the wide range of disciplines such as medicine, nutrition, food production, agriculture, material science and others. They excel not only in their non-toxicity and biodegradability but also in their easy preparation. As well as inorganic particles, a protein corona (PC) around polysaccharide nanoparticles is formed in biofluids. Moreover, it has been considered that the overall response of the organism to nanoparticles presence depends on the PC. This review summarises scientific publications about the structural chemistry of polysaccharide nanoparticles and their impact on theranostic applications. Three strategies of implementation of the PC in theranostics have been discussed: I) Utilisation of the PC in therapy; II) How the composition of the PC is analysed for specific disease markers; III) How the formed PC can interact with the immune system and enhances the immunomodulation or immunoelimination. Thus, the findings from this review can contribute to improve the design of drug delivery systems. However, it is still necessary to elucidate the mechanisms of nano-bio interactions and discover new connections in nanoscale research.

• MeSH
• adjuvancia imunologická terapeutické užití   MeSH
• ateroskleróza diagnostické zobrazování   MeSH
• biologické markery analýza   MeSH
• humorální imunita účinky léků   MeSH
• lidé MeSH
• nádory diagnostické zobrazování   MeSH
• nanočástice chemie   terapeutické užití   MeSH
• polysacharidy chemie   terapeutické užití   MeSH
• proteinová korona * imunologie   MeSH
• teranostická nanomedicína metody   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH

Glucan particles (GPs) from Saccharomyces cerevisiae consist mainly of β-1,3-d-glucan. Curcumin is a phenolic compound of plant origin. A 24 h incubation with a mixture of GPs and curcumin increased the expression of the Nrf2 protein and increased the activation of the Nrf2-ARE system significantly.

• MeSH
• antioxidancia * chemie   metabolismus   farmakologie   MeSH
• buňky Hep G2 MeSH
• faktor 2 související s NF-E2 metabolismus   MeSH
• glukany chemie   MeSH
• kurkumin * chemie   farmakologie   MeSH
• lidé MeSH
• oxidační stres účinky léků   MeSH
• příprava léků MeSH
• Saccharomyces cerevisiae chemie   MeSH
• THP-1 buňky MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH