11-Keto-testosterone and other androgens of adrenal origin
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články, přehledy
PubMed
33094617
PubMed Central
PMC8603739
DOI
10.33549/physiolres.934516
PII: 934516
Knihovny.cz E-zdroje
- MeSH
- androgeny chemie metabolismus MeSH
- antagonisté androgenů terapeutické užití MeSH
- cílená molekulární terapie MeSH
- kongenitální adrenální hyperplazie farmakoterapie metabolismus patologie MeSH
- lidé MeSH
- nádory prostaty farmakoterapie metabolismus patologie MeSH
- testosteron analogy a deriváty antagonisté a inhibitory metabolismus MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Názvy látek
- 11-ketotestosterone MeSH Prohlížeč
- androgeny MeSH
- antagonisté androgenů MeSH
- testosteron MeSH
The adrenal glands produce significant amounts of steroid hormones and their metabolites, with various levels of androgenic activities. Until recently, the androgenic potency of these adrenal-derived compounds were not well known, but some recent studies have shown that the production of 11-oxo- and 11beta-hydroxy-derived testosterone and dihydrotestosterone evidently have high androgenic activity. This fact has clinical importance, for instance, in various types of congenital adrenal hyperplasia with androgenization or polycystic ovarian syndrome, and laboratory determinations of these substances could help to better evaluate the total androgen pressure in patients with these disorders. Another area of concern is the treatment of prostate cancer with androgen deprivation, which loses effectiveness after a certain time. The concurrent blocking of the secretion of adrenal C(19)-steroids, whether using corticoids or adrenostatics, could increase the effectiveness of androgen-deprivation therapy.
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