Electrophoretically Deposited Layers of Octahedral Molybdenum Cluster Complexes: A Promising Coating for Mitigation of Pathogenic Bacterial Biofilms under Blue Light
Language English Country United States Media print-electronic
Document type Journal Article
- Keywords
- biofilm, electrophoretic deposition, luminescence, molybdenum cluster complex, phototoxicity, singlet oxygen,
- MeSH
- Biofilms drug effects MeSH
- Enterococcus faecalis physiology MeSH
- Escherichia coli physiology MeSH
- Photosensitizing Agents chemistry pharmacology MeSH
- Coordination Complexes chemistry pharmacology MeSH
- Molybdenum chemistry MeSH
- Singlet Oxygen chemistry metabolism MeSH
- Glass chemistry MeSH
- Staphylococcus aureus physiology MeSH
- Light * MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Photosensitizing Agents MeSH
- Coordination Complexes MeSH
- Molybdenum MeSH
- Singlet Oxygen MeSH
The fight against infective microorganisms is becoming a worldwide priority due to serious concerns about the rising numbers of drug-resistant pathogenic bacteria. In this context, the inactivation of pathogens by singlet oxygen, O2(1Δg), produced by photosensitizers upon light irradiation has become an attractive strategy to combat drug-resistant microbes. To achieve this goal, we electrophoretically deposited O2(1Δg)-photosensitizing octahedral molybdenum cluster complexes on indium-tin oxide-coated glass plates. This procedure led to the first example of molecular photosensitizer layers able to photoinactivate bacterial biofilms. We delineated the morphology, composition, luminescence, and singlet oxygen formation of these layers and correlated these features with their antibacterial activity. Clearly, continuous 460 nm light irradiation imparted the layers with strong antibacterial properties, and the activity of these layers inhibited the biofilm formation and eradicated mature biofilms of Gram-positive Staphylococcus aureus and Enterococcus faecalis, as well as, Gram-negative Pseudomonas aeruginosa and Escherichia coli bacterial strains. Overall, the microstructure-related oxygen diffusivity of the layers and the water stability of the complexes were the most critical parameters for the efficient and durable use. These photoactive layers are attractive for the design of antibacterial surfaces activated by visible light and include additional functionalities such as the conversion of harmful UV/blue light to red light or oxygen sensing.
References provided by Crossref.org
Octahedral Molybdenum Cluster-Based Nanomaterials for Potential Photodynamic Therapy
