The fight against infective microorganisms is becoming a worldwide priority due to serious concerns about the rising numbers of drug-resistant pathogenic bacteria. In this context, the inactivation of pathogens by singlet oxygen, O2(1Δg), produced by photosensitizers upon light irradiation has become an attractive strategy to combat drug-resistant microbes. To achieve this goal, we electrophoretically deposited O2(1Δg)-photosensitizing octahedral molybdenum cluster complexes on indium-tin oxide-coated glass plates. This procedure led to the first example of molecular photosensitizer layers able to photoinactivate bacterial biofilms. We delineated the morphology, composition, luminescence, and singlet oxygen formation of these layers and correlated these features with their antibacterial activity. Clearly, continuous 460 nm light irradiation imparted the layers with strong antibacterial properties, and the activity of these layers inhibited the biofilm formation and eradicated mature biofilms of Gram-positive Staphylococcus aureus and Enterococcus faecalis, as well as, Gram-negative Pseudomonas aeruginosa and Escherichia coli bacterial strains. Overall, the microstructure-related oxygen diffusivity of the layers and the water stability of the complexes were the most critical parameters for the efficient and durable use. These photoactive layers are attractive for the design of antibacterial surfaces activated by visible light and include additional functionalities such as the conversion of harmful UV/blue light to red light or oxygen sensing.

CNRS Saint Gobain NIMS UMI 3629 Laboratory for Innovative Key Materials and Structures National Institute for Materials Science 1 1 Namiki 305 0044 Tsukuba Japan

Department of Biochemistry and Microbiology University of Chemistry and Technology Prague Technická 5 166 28 Praha 6 Czech Republic

Institute of Inorganic Chemistry of the Czech Academy of Sciences Řež 1001 250 68 Husinec Řež Czech Republic

J Heyrovský Institute of Physical Chemistry of the Czech Academy of Sciences Dolejškova 3 182 23 Praha 8 Czech Republic

Research Center for Functional Materials National Institute for Materials Science 1 2 1 Sengen Tsukuba Ibaraki 305 0047 Japan

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