Sebaceous Tumors of the Skin: A Study of 145 Lesions From 136 Patients Correlating Pathologic Features and DNA Mismatch Repair Staining Pattern
Language English Country United States Media print
Document type Journal Article
PubMed
33201015
DOI
10.1097/dad.0000000000001691
PII: 00000372-202103000-00002
Knihovny.cz E-resources
- MeSH
- Adenoma metabolism pathology MeSH
- DNA-Binding Proteins metabolism MeSH
- Adult MeSH
- MutS Homolog 2 Protein metabolism MeSH
- Immunohistochemistry MeSH
- Carcinoma metabolism pathology MeSH
- Extremities MeSH
- Middle Aged MeSH
- Humans MeSH
- Mismatch Repair Endonuclease PMS2 metabolism MeSH
- Adolescent MeSH
- Young Adult MeSH
- MutL Protein Homolog 1 metabolism MeSH
- Head and Neck Neoplasms metabolism pathology MeSH
- Sebaceous Gland Neoplasms metabolism pathology MeSH
- Face MeSH
- DNA Mismatch Repair MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Scalp MeSH
- Torso MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- DNA-Binding Proteins MeSH
- G-T mismatch-binding protein MeSH Browser
- MutS Homolog 2 Protein MeSH
- Mismatch Repair Endonuclease PMS2 MeSH
- MLH1 protein, human MeSH Browser
- MSH2 protein, human MeSH Browser
- MutL Protein Homolog 1 MeSH
- PMS2 protein, human MeSH Browser
Sebaceous neoplasms occur sporadically or in the setting of Muir-Torre syndrome. The data regarding the correlation of pathologic features and DNA mismatch repair (MMR) staining pattern in sebaceous tumors of the skin are very scanty and based on relatively small series of patients. The goal of this study was to correlate MMR staining pattern with selected morphological features in a series of 145 sebaceous neoplasms (sebaceous adenoma, sebaceoma, and extraocular sebaceous carcinoma) from 136 patients. Cystic change, intratumoral mucin deposits, squamous metaplasia in the absence of keratoacanthoma-like changes, ulceration, intratumoral and peritumoral lymphocytes (in cases without epidermal ulceration), and intertumoral heterogeneity proved to be significantly associated with MMR deficiency. Identification of any of these changes, alone or in combination, should prompt further investigation of the patient to exclude Muir-Torre Syndrome. Our study also confirms the previously published observation that the diagnosis and tumor location are significantly associated with MMR deficiency.
Bioptical Laboratory Pilsen Czech Republic; and
Department of Dermatology University Hospital Zurich Switzerland
Department of Pathology Medical Faculty Saint Petersburg State University Saint Petersburg Russia
Department of Pathology Saint Petersburg Medico Social Institute Saint Petersburg Russia
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