Influence of Mesenchymal Stem Cell Administration on The Outcome of Partial Liver Resection in a Porcine Model of Sinusoidal Obstruction Syndrome
Jazyk angličtina Země Řecko Médium print
Typ dokumentu časopisecké články
PubMed
33288574
DOI
10.21873/anticanres.14704
PII: 40/12/6817
Knihovny.cz E-zdroje
- Klíčová slova
- Sinusoidal obstruction syndrome, colorectal cancer, liver metastases, liver resection, mesenchymal stem cells, monocrotaline,
- MeSH
- biologické markery MeSH
- hepatektomie * metody MeSH
- imunofenotypizace MeSH
- imunohistochemie MeSH
- jaterní žilní okluze etiologie patologie terapie MeSH
- kolorektální nádory patologie MeSH
- kombinovaná terapie MeSH
- mezenchymální kmenové buňky * cytologie MeSH
- modely nemocí na zvířatech MeSH
- nádory jater komplikace sekundární MeSH
- prasata MeSH
- transplantace mezenchymálních kmenových buněk * MeSH
- výsledek terapie MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- biologické markery MeSH
BACKGROUND: In patients with colorectal liver metastases, the possibility for radical liver resection can be limited by oxaliplatin-induced sinusoidal obstruction syndrome (SOS). This study investigates the potential of mesenchymal stem cells (MSC) to improve the outcome of liver resections in pigs with SOS. MATERIALS AND METHODS: SOS was induced in all animals (n=20) on day 0. Animals in the experimental group (n=8) received allogeneic MSC on day 7. Liver resection was performed in all animals on day 14 and the animals were observed until day 28. Ultrasound volumetry, biochemical analysis and histological examination of liver parenchyma was performed during the follow-up period. RESULTS: Six animals from the control group died prematurely, while all animals survived in the experimental group. According to histology, biochemical analysis and ultrasound volumetry, there were no significant differences between the groups documenting the effect of MSC. CONCLUSION: Single dose allogeneic MSC administration improved survival of animals with SOS undergoing partial liver resection. Further experiments with different timing of liver resection and MSC administration should be performed to investigate the effect of MSC in more detail.
Biomedical Center Faculty of Medicine in Pilsen Charles University Pilsen Czech Republic
Department of Anatomy Faculty of Medicine in Pilsen Charles University Pilsen Czech Republic
Department of Medical Imaging Faculty of Medicine in Pilsen Charles University Pilsen Czech Republic
Department of Surgery Faculty of Medicine in Pilsen Charles University Pilsen Czech Republic
Department of Surgery Faculty of Medicine in Pilsen Charles University Pilsen Czech Republic;
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