Tissue mRNA for S100A4, S100A6, S100A8, S100A9, S100A11 and S100P Proteins in Colorectal Neoplasia: A Pilot Study
Jazyk angličtina Země Švýcarsko Médium electronic
Typ dokumentu časopisecké články
Grantová podpora
academic project PROGRES Q40-15
Univerzita Karlova v Praze
PubMed
33466593
PubMed Central
PMC7828666
DOI
10.3390/molecules26020402
PII: molecules26020402
Knihovny.cz E-zdroje
- Klíčová slova
- S100 proteins, colorectal neoplasia, large intestine, mRNA,
- MeSH
- adenom genetika metabolismus patologie MeSH
- kalgranulin A genetika metabolismus MeSH
- kalgranulin B genetika metabolismus MeSH
- kolorektální nádory genetika metabolismus patologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- messenger RNA genetika metabolismus MeSH
- nádorové biomarkery genetika metabolismus MeSH
- nádorové proteiny genetika metabolismus MeSH
- následné studie MeSH
- pilotní projekty MeSH
- prognóza MeSH
- protein S100A6 genetika metabolismus MeSH
- proteiny buněčného cyklu genetika metabolismus MeSH
- proteiny S100 genetika metabolismus MeSH
- proteiny vázající vápník genetika metabolismus MeSH
- S100 kalcium vázající protein A4 genetika metabolismus MeSH
- senioři MeSH
- studie případů a kontrol MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- kalgranulin A MeSH
- kalgranulin B MeSH
- messenger RNA MeSH
- nádorové biomarkery MeSH
- nádorové proteiny MeSH
- protein S100A6 MeSH
- proteiny buněčného cyklu MeSH
- proteiny S100 MeSH
- proteiny vázající vápník MeSH
- S100 kalcium vázající protein A4 MeSH
- S100A11 protein, human MeSH Prohlížeč
- S100A4 protein, human MeSH Prohlížeč
- S100A6 protein, human MeSH Prohlížeč
- S100A8 protein, human MeSH Prohlížeč
- S100A9 protein, human MeSH Prohlížeč
- S100P protein, human MeSH Prohlížeč
S100 proteins are involved in the pathogenesis of sporadic colorectal carcinoma through different mechanisms. The aim of our study was to assess tissue mRNA encoding S100 proteins in patients with non-advanced and advanced colorectal adenoma. Mucosal biopsies were taken from the caecum, transverse colon and rectum during diagnostic and/or therapeutic colonoscopy. Another biopsy was obtained from adenomatous tissue in the advanced adenoma group. The tissue mRNA for each S100 protein (S100A4, S100A6, S100A8, S100A9, S100A11 and S100P) was investigated. Eighteen biopsies were obtained from the healthy mucosa in controls and the non-advanced adenoma group (six individuals in each group) and thirty biopsies in the advanced adenoma group (ten patients). Nine biopsies were obtained from advanced adenoma tissue (9/10 patients). Significant differences in mRNA investigated in the healthy mucosa were identified between (1) controls and the advanced adenoma group for S100A6 (p = 0.012), (2) controls and the non-advanced adenoma group for S100A8 (p = 0.033) and (3) controls and the advanced adenoma group for S100A11 (p = 0.005). In the advanced adenoma group, differences between the healthy mucosa and adenomatous tissue were found in S100A6 (p = 0.002), S100A8 (p = 0.002), S100A9 (p = 0.021) and S100A11 (p = 0.029). Abnormal mRNA expression for different S100 proteins was identified in the pathological adenomatous tissue as well as in the morphologically normal large intestinal mucosa.
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