The Connection between MicroRNAs from Visceral Adipose Tissue and Non-Alcoholic Fatty Liver Disease
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články, přehledy
Grantová podpora
PROGRES Q40/02
Univerzita Karlova v Praze
PROGRES Q40/11
Univerzita Karlova v Praze
PubMed
33855952
DOI
10.14712/18059694.2021.1
PII: am_2021064010001
Knihovny.cz E-zdroje
- Klíčová slova
- NAFLD, NASH, adipose tissue, inflammation, lipid metabolism, miRNA, microRNA, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis,
- MeSH
- lidé MeSH
- mikro RNA metabolismus MeSH
- nealkoholová steatóza jater metabolismus MeSH
- nitrobřišní tuk metabolismus MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Názvy látek
- mikro RNA MeSH
Non-Alcoholic Fatty Liver Disease (NAFLD) is one of the most important causes of liver disease worldwide leading the foreground cause of liver transplantation. Recently miRNAs, small non-coding molecules were identified as an important player in the negative translational regulation of many protein-coding genes involved in hepatic metabolism. Visceral adipose tissue was found to take part in lipid and glucose metabolism and to release many inflammatory mediators that may contribute to progression of NAFLD from simple steatosis to Non-Alcoholic SteatoHepatitis. Since visceral adipose tissue enlargement and dysregulated levels of miRNAs were observed in patients with NAFLD, the aim of this paper is to reflect the current knowledge of the role of miRNAs released from visceral adipose tissue and NAFLD.
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