Colorectal cancer incidence, mortality, and stage distribution in European countries in the colorectal cancer screening era: an international population-based study
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články, multicentrická studie, práce podpořená grantem
PubMed
34048685
DOI
10.1016/s1470-2045(21)00199-6
PII: S1470-2045(21)00199-6
Knihovny.cz E-zdroje
- MeSH
- časná detekce nádoru * MeSH
- časové faktory MeSH
- dospělí MeSH
- incidence MeSH
- kolorektální nádory epidemiologie mortalita patologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- prediktivní hodnota testů MeSH
- registrace MeSH
- rozložení podle pohlaví MeSH
- senioři MeSH
- staging nádorů MeSH
- věkové rozložení MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Evropa epidemiologie MeSH
BACKGROUND: Colorectal cancer screening programmes and uptake vary substantially across Europe. We aimed to compare changes over time in colorectal cancer incidence, mortality, and stage distribution in relation to colorectal cancer screening implementation in European countries. METHODS: Data from nearly 3·1 million patients with colorectal cancer diagnosed from 2000 onwards (up to 2016 for most countries) were obtained from 21 European countries, and were used to analyse changes over time in age-standardised colorectal cancer incidence and stage distribution. The WHO mortality database was used to analyse changes over time in age-standardised colorectal cancer mortality over the same period for the 16 countries with nationwide data. Incidence rates were calculated for all sites of the colon and rectum combined, as well as the subsites proximal colon, distal colon, and rectum. Average annual percentage changes (AAPCs) in incidence and mortality were estimated and relevant patterns were descriptively analysed. FINDINGS: In countries with long-standing programmes of screening colonoscopy and faecal tests (ie, Austria, the Czech Republic, and Germany), colorectal cancer incidence decreased substantially over time, with AAPCs ranging from -2·5% (95% CI -2·8 to -2·2) to -1·6% (-2·0 to -1·2) in men and from -2·4% (-2·7 to -2·1) to -1·3% (-1·7 to -0·9) in women. In countries where screening programmes were implemented during the study period, age-standardised colorectal cancer incidence either remained stable or increased up to the year screening was implemented. AAPCs for these countries ranged from -0·2% (95% CI -1·4 to 1·0) to 1·5% (1·1 to 1·8) in men and from -0·5% (-1·7 to 0·6) to 1·2% (0·8 to 1·5) in women. Where high screening coverage and uptake were rapidly achieved (ie, Denmark, the Netherlands, and Slovenia), age-standardised incidence rates initially increased but then subsequently decreased. Conversely, colorectal cancer incidence increased in most countries where no large-scale screening programmes were available (eg, Bulgaria, Estonia, Norway, and Ukraine), with AAPCs ranging from 0·3% (95% CI 0·1 to 0·5) to 1·9% (1·2 to 2·6) in men and from 0·6% (0·4 to 0·8) to 1·1% (0·8 to 1·4) in women. The largest decreases in colorectal cancer mortality were seen in countries with long-standing screening programmes. INTERPRETATION: We observed divergent trends in colorectal cancer incidence, mortality, and stage distribution across European countries, which appear to be largely explained by different levels of colorectal cancer screening implementation. FUNDING: German Cancer Aid (Deutsche Krebshilfe) and the German Federal Ministry of Education and Research.
Austrian National Cancer Registry Statistics Austria Vienna Austria
Basque Country Cancer Registry Vitoria Gasteiz Spain
Belgian Cancer Registry Brussels Belgium
Bulgarian National Cancer Registry University Hospital of Oncology Sofia Bulgaria
Cancer Registry Bern Solothurn Bern Switzerland
Cancer Registry of Doubs Centre Hospitalier Régional Universitaire Besançon Besançon France
Cancer Registry of Isère French Network of Cancer Registries Grenoble France
Cancer Registry of Norway Oslo Norway
Cancer Registry of Schleswig Holstein Lübeck Germany
Danish Cancer Society Research Center Copenhagen Denmark
Estonian Cancer Registry National Institute for Health Development Tallinn Estonia
Lithuanian Cancer Registry National Cancer Institute Vilnius Lithuania
National Cancer Registry Ireland Cork Ireland
Piedmont Cancer Registry Turin Italy
Portuguese National Cancer Registry Portuguese Oncology Institute of Lisbon Lisbon Portugal
Slovenian Cancer Registry Institute of Oncology Ljubljana Slovenia
Citace poskytuje Crossref.org
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