On the role of sex steroids in biological functions by classical and non-classical pathways. An update
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem, přehledy
Grantová podpora
F31 MH118822
NIMH NIH HHS - United States
R01 MH107886
NIMH NIH HHS - United States
R15 GM118304
NIGMS NIH HHS - United States
PubMed
34089761
PubMed Central
PMC8523217
DOI
10.1016/j.yfrne.2021.100926
PII: S0091-3022(21)00028-5
Knihovny.cz E-zdroje
- Klíčová slova
- Brain structures, Classical/non-classical signaling, Gonadal hormones, Intracellular receptors, Sex steroids, Transmembrane receptors,
- MeSH
- estradiol * MeSH
- estrogeny MeSH
- hypothalamus MeSH
- lidé MeSH
- pohlavní steroidní hormony * MeSH
- těhotenství MeSH
- testosteron MeSH
- Check Tag
- lidé MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Research Support, N.I.H., Extramural MeSH
- Názvy látek
- estradiol * MeSH
- estrogeny MeSH
- pohlavní steroidní hormony * MeSH
- testosteron MeSH
The sex steroid hormones (SSHs) play several roles in regulation of various processes in the cardiovascular, immune, muscular and neural systems. SSHs affect prenatal and postnatal development of various brain structures, including regions associated with important physiological, behavioral, cognitive, and emotional functions. This action can be mediated by either intracellular or transmembrane receptors. While the classical mechanisms of SSHs action are relatively well examined, the physiological importance of non-classical mechanism of SSHs action through membrane-associated and transmembrane receptors in the brain remains unclear. The most recent summary describing the role of SSHs in different body systems is lacking. Therefore, the aim of this review is to discuss classical and non-classical signaling pathways of testosterone and estradiol action via their receptors at functional, cellular, tissue level and to describe the effects on various body systems and behavior. Particular emphasis will be on brain regions including the hippocampus, hypothalamus, frontal cortex and cerebellum.
Department of Psychology University of Wisconsin Milwaukee Milwaukee WI USA
Institute of Physiology 1st Faculty of Medicine Charles University Prague Czech Republic
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Steroid Sulfation in Neurodegenerative Diseases