BACKGROUND: Acute Stanford type A aortic dissection (TAAD) is a life-threatening condition. Surgery is usually performed as a salvage procedure and is associated with significant postoperative early mortality and morbidity. Understanding the patient's conditions and treatment strategies which are associated with these adverse events is essential for an appropriate management of acute TAAD. METHODS: Nineteen centers of cardiac surgery from seven European countries have collaborated to create a multicentre observational registry (ERTAAD), which will enroll consecutive patients who underwent surgery for acute TAAD from January 2005 to March 2021. Analysis of the impact of patient's comorbidities, conditions at referral, surgical strategies and perioperative treatment on the early and late adverse events will be performed. The investigators have developed a classification of the urgency of the procedure based on the severity of preoperative hemodynamic conditions and malperfusion secondary to acute TAAD. The primary clinical outcomes will be in-hospital mortality, late mortality and reoperations on the aorta. Secondary outcomes will be stroke, acute kidney injury, surgical site infection, reoperation for bleeding, blood transfusion and length of stay in the intensive care unit. DISCUSSION: The analysis of this multicentre registry will allow conclusive results on the prognostic importance of critical preoperative conditions and the value of different treatment strategies to reduce the risk of early adverse events after surgery for acute TAAD. This registry is expected to provide insights into the long-term durability of different strategies of surgical repair for TAAD. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04831073 .

Cardiac Surgery Department University of Udine Udine Italy

Cardiac Surgery University Hospitals Leuven Leuven Belgium

Cardiovascular and Thoracic Surgery Saint Luc's Hospital Catholic University of Louvain Brussels Belgium

Department of Cardiac Surgery AZ St Jan Bruges Belgium

Department of Cardiac Surgery Glenfield Hospital University Hospitals of Leicester Leicester UK

Department of Cardiac Surgery University Hospital Antwerp Edegem Belgium

Department of Cardiac Surgery University of Turin Turin Italy

Department of Cardio Thoracic Surgery Jean Minjoz University Hospital Besançon France

Department of Cardiothoracic Surgery Münster University Hospital Münster Germany

Department of Cardiovascular Surgery German Aortic Centre Hamburg University Heart and Vascular Centre Hamburg Hamburg Germany

Department of Cardiovascular Surgery Ziekenhuis Oost Limburg Genk Belgium

Division of Cardiac Surgery University of Verona Medical School Verona Italy

Heart and Lung Center Helsinki University Hospital and University of Helsinki P O Box 340 Haartmaninkatu 4 00029 Helsinki Finland

Institute of Clinical and Experimental Medicine Prague Czech Republic

Leipzig Heart center Leipzig Germany

Liverpool Cardiovascular Surgery Liverpool Heart and Chest Hospital Faculty of Health and Life Sciences Liverpool Centre for Cardiovascular Science University of Liverpool Liverpool UK

Northern General Hospital Herries Road Sheffield UK

Research Unit of Surgery Anesthesia and Critical Care University of Oulu Oulu Finland

Service de Chirurgie Thoracique et Cardio vasculaire Hôpital Henri Mondor Assistance Publique Hôpitaux de Paris Créteil France

Southampton University Hospital Southampton UK

UK Aortic Surgery Group Wessex Cardiothoracic Centre Division of Cardiac Surgery Southampton University Hospital Southampton UK

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ClinicalTrials.gov
NCT04831073