Determination of acyclovir and its metabolite 9-carboxymethoxymethylguanide in human serum by ultra-high-performance liquid chromatography-tandem mass spectrometry
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články
PubMed
34165890
DOI
10.1002/jssc.202100241
Knihovny.cz E-zdroje
- Klíčová slova
- 9-carboxymethoxymethylguanine, acyclovir, mass spectrometry,
- MeSH
- acetonitrily chemie MeSH
- acyklovir analýza MeSH
- chemické techniky analytické normy MeSH
- dospělí MeSH
- formiáty chemie MeSH
- guanin analogy a deriváty analýza MeSH
- hmotnostní spektrometrie MeSH
- kalibrace MeSH
- lidé středního věku MeSH
- lidé MeSH
- limita detekce MeSH
- mladiství MeSH
- mladý dospělý MeSH
- reprodukovatelnost výsledků MeSH
- řízení kvality MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- tandemová hmotnostní spektrometrie metody MeSH
- vysokoúčinná kapalinová chromatografie metody MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- 9-carboxymethoxymethylguanine MeSH Prohlížeč
- acetonitrile MeSH Prohlížeč
- acetonitrily MeSH
- acyklovir MeSH
- formiáty MeSH
- formic acid MeSH Prohlížeč
- guanin MeSH
A simple and rapid ultra-high-performance liquid chromatography coupled with mass spectrometry method was developed for acyclovir and its metabolite 9-carboxymethoxymethylguanine in human serum. After precipitation of serum samples with 0.1% formic acid in acetonitrile/methanol (40:60, v/v), components were separated on a Luna Omega C18 column (1.6 μm; 2.1 × 150 mm) at 40°C. Mobile phase A (2 mmol/L ammonium acetate, 0.1% formic acid in 5% acetonitrile, v/v/v) and mobile phase B (2 mmol/L ammonium acetate, 0.1% formic acid in 95% acetonitrile, v/v/v) were used for gradient elution. A linear calibration curve was obtained over the range of 0.05-50 mg/L, and the correlation coefficients were better than 0.999. The limit of quantitation was 0.05 mg/L for both analytes. The intra- and interday accuracy and precision at three concentration levels ranged between 1.6 and 13.3%, and recoveries were achieved with a range between 92.2 and 114.2%. This method was developed and validated for the therapeutic monitoring of acyclovir in patients.
Clinic of Infectious Medicine Faculty of Medicine University of Ostrava Ostrava Czech Republic
Clinic of Infectious Medicine University Hospital Ostrava Ostrava Czech Republic
Department of Clinical Pharmacology Faculty of Medicine University of Ostrava Ostrava Czech Republic
Zobrazit více v PubMed
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