Induction of muscle thermogenesis by high-fat diet in mice: association with obesity-resistance
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
18492779
DOI
10.1152/ajpendo.90256.2008
PII: 90256.2008
Knihovny.cz E-zdroje
- MeSH
- aminoimidazolkarboxamid analogy a deriváty metabolismus MeSH
- bazální metabolismus MeSH
- dietní tuky aplikace a dávkování metabolismus MeSH
- kosterní svaly metabolismus fyziologie MeSH
- kyseliny mastné neesterifikované krev MeSH
- multienzymové komplexy metabolismus MeSH
- myši inbrední C57BL MeSH
- myši MeSH
- náhodné rozdělení MeSH
- nepřímá kalorimetrie MeSH
- novorozená zvířata MeSH
- obezita etiologie metabolismus MeSH
- protein-serin-threoninkinasy metabolismus MeSH
- proteinkinasy aktivované AMP MeSH
- ribonukleotidy metabolismus MeSH
- spotřeba kyslíku fyziologie MeSH
- tělesná hmotnost fyziologie MeSH
- tělesná teplota fyziologie MeSH
- termogeneze fyziologie MeSH
- triglyceridy krev MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- AICA ribonucleotide MeSH Prohlížeč
- aminoimidazolkarboxamid MeSH
- dietní tuky MeSH
- kyseliny mastné neesterifikované MeSH
- multienzymové komplexy MeSH
- protein-serin-threoninkinasy MeSH
- proteinkinasy aktivované AMP MeSH
- ribonukleotidy MeSH
- triglyceridy MeSH
The obesogenic effect of a high-fat (HF) diet is counterbalanced by stimulation of energy expenditure and lipid oxidation in response to a meal. The aim of this study was to reveal whether muscle nonshivering thermogenesis could be stimulated by a HF diet, especially in obesity-resistant A/J compared with obesity-prone C57BL/6J (B/6J) mice. Experiments were performed on male mice born and maintained at 30 degrees C. Four-week-old mice were randomly weaned onto a low-fat (LF) or HF diet for 2 wk. In the A/J LF mice, cold exposure (4 degrees C) resulted in hypothermia, whereas the A/J HF, B/6J LF, and B/6J HF mice were cold tolerant. Cold sensitivity of the A/J LF mice was associated with a relatively low whole body energy expenditure under resting conditions, which was normalized by the HF diet. In both strains, the HF diet induced uncoupling protein-1-mediated thermogenesis, with a stronger induction in A/J mice. Only in A/J mice: 1) the HF diet augmented activation of whole body lipid oxidation by cold; and 2) at 30 degrees C, oxygen consumption, total content, and phosphorylation of AMP-activated protein kinase (AMPK), and AICAR-stimulated palmitate oxidation in soleus muscle was increased by the HF diet in parallel with significantly increased leptinemia. Gene expression data in soleus muscle of the A/J HF mice indicated a shift from carbohydrate to fatty acid oxidation. Our results suggest a role for muscle nonshivering thermogenesis and lipid oxidation in the obesity-resistant phenotype of A/J mice and indicate that a HF diet could induce thermogenesis in oxidative muscle, possibly via the leptin-AMPK axis.
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