A dark side to NS1 antibodies?
Status PubMed-not-MEDLINE Language English Country United States Media print-electronic
Document type Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Comment
Grant support
P01 AI138938
NIAID NIH HHS - United States
U19AI111825
NIH HHS - United States
U19 AI111825
NIAID NIH HHS - United States
U01 AI151698
NIAID NIH HHS - United States
196866
Swiss National Science Foundation - Switzerland
PubMed
34319348
PubMed Central
PMC8321876
DOI
10.1084/jem.20211348
PII: 212515
Knihovny.cz E-resources
- Publication type
- Journal Article MeSH
- Comment MeSH
- Research Support, Non-U.S. Gov't MeSH
- Research Support, N.I.H., Extramural MeSH
The NS1 protein of flaviviruses is taking center stage. Recent work has made it an attractive target for development of vaccines and immunotherapeutics. Cavazzoni and colleagues (2021. J. Exp. Med.https://doi.org/10.1084/jem.20210580) now reveal a dark side to NS1, linking it to the development of self-reactive antibodies.
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Avirutnan, P., et al. . 2010. J. Exp. Med. 10.1084/jem.20092545 PubMed DOI PMC
Beatty, P.R., et al. . 2015. Sci. Transl. Med. 10.1126/scitranslmed.aaa3787 PubMed DOI
Biering, S.B., et al. . 2021. Science. 10.1126/science.abc0476 DOI
Carpio, K.L., and Barrett A.D.T.. 2021. Vaccines (Basel). 10.3390/vaccines9060622 PubMed DOI PMC
Cavazzoni, C.B., et al. . 2021. J. Exp. Med. 10.1084/jem.20210580 DOI
Gould, E.A., and Solomon T.. 2008. Lancet. 10.1016/S0140-6736(08)60238-X PubMed DOI
Gould, E.A., et al. . 1986. J. Gen. Virol. 10.1099/0022-1317-67-3-591 DOI
Grijalva, I., et al. . 2020. PLoS Negl. Trop. Dis. 10.1371/journal.pntd.0008032 DOI
Gyawali, N., et al. . 2016. J. Vector Borne Dis. 53:293–304. PubMed
Ishikawa, T., et al. . 2014. Vaccine. 10.1016/j.vaccine.2014.01.040 DOI
Lin, C.F., et al. . 2008. Lab. Invest. 10.1038/labinvest.2008.70 DOI
Lindenbach, B.D., and Rice C.M.. 2003. Adv. Virus Res. 10.1016/S0065-3527(03)59002-9 PubMed DOI
Modhiran, N., et al. . 2021. Science. 10.1126/science.abb9425 DOI
Radic, M.Z., and Weigert M.. 1994. Annu. Rev. Immunol. 10.1146/annurev.iy.12.040194.002415 PubMed DOI
Rey, F.A., et al. . 2018. EMBO Rep. 10.15252/embr.201745302 PubMed DOI PMC
Schlesinger, J.J., et al. . 1985. J. Immunol. 135:2805–2809. PubMed