Adipose tissue immune cells in obesity, type 2 diabetes mellitus and cardiovascular diseases
Language English Country Great Britain, England Media electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
34592714
DOI
10.1530/joe-21-0159
PII: JOE-21-0159.R1
Knihovny.cz E-resources
- Keywords
- T2DM, adipose tissue, cardiovascular diseases, immune cells, obesity,
- MeSH
- Cytokines metabolism MeSH
- Diabetes Mellitus, Type 2 immunology metabolism MeSH
- Immune System metabolism physiology MeSH
- Cardiovascular Diseases etiology immunology metabolism MeSH
- Humans MeSH
- Macrophages pathology physiology MeSH
- Obesity immunology metabolism MeSH
- Risk Factors MeSH
- Adipose Tissue immunology metabolism MeSH
- Inflammation immunology metabolism MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Cytokines MeSH
Immune cells are an inseparable component of adipose tissue intimately involved in most of its functions. Physiologically, they regulate adipose tissue homeostasis, while in case of adipose tissue stress, immune cells are able to change their phenotype, enhance their count and subsequently contribute to the development and maintenance of local adipose tissue inflammation. Immune cells are an important source of inflammatory cytokines and other pro-inflammatory products that further influence not only surrounding tissues but via systemic circulation also the whole organism being thus one of the main factors responsible for the transition from simple obesity to associated metabolic and cardiovascular complications. The purpose of this review is to summarize current knowledge on different adipose tissue immune cell subsets and their role in the development of obesity, type 2 diabetes mellitus and cardiovascular diseases.
Diabetes Centre Institute for Clinical and Experimental Medicine Prague Czech Republic
Experimental Medicine Centre Institute for Clinical and Experimental Medicine Prague Czech Republic
References provided by Crossref.org
