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PubMed

Záznam pochází z PubMed

COVID-19 pandemic, mechanical reperfusion and 30-day mortality in ST elevation myocardial infarction

Heart (British Cardiac Society). 2022 Mar ; 108 (6) : 458-466. [epub] 20211028

Heart
ISSN 1468-201X | 1355-6037
Zdroj

Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic

Typ dokumentu časopisecké články, multicentrická studie

Perzistentní odkaz https://www.medvik.cz/link/pmid34711661

PubMed 34711661
DOI 10.1136/heartjnl-2021-319750
PII: heartjnl-2021-319750
Knihovny.cz E-zdroje

Klíčová slova
COVID-19, myocardial infarction, percutaneous coronary intervention,
MeSH
čas zasáhnout při rozvinutí nemoci trendy MeSH
časové faktory MeSH
COVID-19 * MeSH
hodnocení rizik MeSH
incidence MeSH
infarkt myokardu s elevacemi ST úseků diagnóza mortalita terapie MeSH
kardiologové trendy MeSH
koronární angioplastika škodlivé účinky mortalita trendy MeSH
lékařská praxe - způsoby provádění trendy MeSH
lidé středního věku MeSH
lidé MeSH
mortalita v nemocnicích trendy MeSH
registrace MeSH
retrospektivní studie MeSH
rizikové faktory MeSH
senioři MeSH
výsledek terapie MeSH
Check Tag
lidé středního věku MeSH
lidé MeSH
mužské pohlaví MeSH
senioři MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH
multicentrická studie MeSH

OBJECTIVE: The initial data of the International Study on Acute Coronary Syndromes - ST Elevation Myocardial Infarction COVID-19 showed in Europe a remarkable reduction in primary percutaneous coronary intervention procedures and higher in-hospital mortality during the initial phase of the pandemic as compared with the prepandemic period. The aim of the current study was to provide the final results of the registry, subsequently extended outside Europe with a larger inclusion period (up to June 2020) and longer follow-up (up to 30 days). METHODS: This is a retrospective multicentre registry in 109 high-volume primary percutaneous coronary intervention (PPCI) centres from Europe, Latin America, South-East Asia and North Africa, enrolling 16 674 patients with ST segment elevation myocardial infarction (STEMI) undergoing PPPCI in March/June 2019 and 2020. The main study outcomes were the incidence of PPCI, delayed treatment (ischaemia time >12 hours and door-to-balloon >30 min), in-hospital and 30-day mortality. RESULTS: In 2020, during the pandemic, there was a significant reduction in PPCI as compared with 2019 (incidence rate ratio 0.843, 95% CI 0.825 to 0.861, p<0.0001). This reduction was significantly associated with age, being higher in older adults (>75 years) (p=0.015), and was not related to the peak of cases or deaths due to COVID-19. The heterogeneity among centres was high (p<0.001). Furthermore, the pandemic was associated with a significant increase in door-to-balloon time (40 (25-70) min vs 40 (25-64) min, p=0.01) and total ischaemia time (225 (135-410) min vs 196 (120-355) min, p<0.001), which may have contributed to the higher in-hospital (6.5% vs 5.3%, p<0.001) and 30-day (8% vs 6.5%, p=0.001) mortality observed during the pandemic. CONCLUSION: Percutaneous revascularisation for STEMI was significantly affected by the COVID-19 pandemic, with a 16% reduction in PPCI procedures, especially among older patients (about 20%), and longer delays to treatment, which may have contributed to the increased in-hospital and 30-day mortality during the pandemic. TRIAL REGISTRATION NUMBER: NCT04412655.

COVID-19 pandemic, mechanical reperfusion and 30-day mortality in ST elevation myocardial infarction

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