Photoaged skin exhibits signs of inflammation, DNA damage and changes in morphology that are visible at the macroscopic and microscopic levels. Photoaging also affects the extracellular matrix (ECM) including hyaluronan (HA), the main polysaccharide component thereof. HA is a structurally simple but biologically complex molecule that serves as a water-retaining component and provides both a scaffold for a number of the proteins of the ECM and the ligand for cellular receptors. The study provides an overview of the literature concerning the changes in HA amount, size and metabolism, and the potential role of HA in photoaging. We also suggest novel HA contributions to photoaging based on our knowledge of the role of HA in other pathological processes, including the senescence and inflammation-triggered ECM reorganization. Moreover, we discuss potential direct or indirect intervention to mitigate photoaging that targets the hyaluronan metabolism, as well as supplementation.

3rd Faculty of Medicine Charles University Prague Czech Republic

Contipro a s Dolní Dobrouč Czech Republic

Department of Radiobiology Faculty of Military Health Sciences University of Defense in Brno Hradec Kralove Czech Republic

Institute of Experimental Biology Faculty of Science Masaryk University Brno Czech Republic

Zobrazit více v PubMed

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Recent Advances of Hyaluronan for Skin Delivery: From Structure to Fabrication Strategies and Applications

Retinoic Acid Grafted to Hyaluronic Acid Activates Retinoid Gene Expression and Removes Cholesterol from Cellular Membranes