Male reproductive functions are an important area affecting men´s overall health and well-being. However, during the last years, there has been observed increasing incidence of male reproductive issues. The radical growth has been recorded parallelly with a massive expanse of industrialization and agricultural chemigation. Many groups of experts have begun to identify several potential factors and substances that may have adverse effects on men´s reproductive health. Since then, xenobiotics have become a major concern of many scientific studies. There is evidence that most of them have multigenerational and transgenerational effects on reproductive health, which is a serious problem for our population. Bisphenol A could be considered as one of the most studied endocrine disruptors. Until now, several negative effects of bisphenol A were associated with reduced weight testes, histological alterations, impairment spermatogenesis, and steroidogenesis as well as with testes or prostate cancer. Due to convincing evidence, bisphenol A has been started to replace by its analogues such as bisphenol B, S, F, in order to eliminate and suppress the risk of exposure to bisphenol A. However, it seems that a lack of toxicological analyses allows using of these hazardous substances in daily life. Their harmful effect was confirmed by the animal in vitro and in vivo models, while the epidemiological studies monitoring the impact of bisphenol analogues on men's reproductive health are markedly limited. This review provides information about the effects of bisphenol on reproductive health in men. At the same time, it is focused on physiological aspects of sperm viability, steroid hormone secretion, sperm motility, or testes histology in relation to bisphenols exposure.

BioFood Centre Faculty of Biotechnology and Food Sciences Slovak University of Agriculture in Nitra Slovak Republic

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ABOAMNEI E, MENDIOLA J, VELA-SORIA F, FERNÁNDEZ MF, OLEA N, JORGENSEN N, SWAN HS, TORRES-CANTERO AM. Urinary bisphenol A concentrations are associated with reproductive parameters in young men. Environ Res. 2018;161:122–128. doi: 10.1016/j.envres.2017.11.002. PubMed DOI

AKINGBEMI BT, SOTTAS CHM, KOULOVA AI, KLINEFELTER GR, HARDY MP. Inhibition of testicular steroidogenesis by the xenoestrogen bisphenol A is associated with reduced pituitary luteinizing hormone secretion and decreased steroidogenic enzyme gene expression in rat Leydig cells. Endocrinology. 2004;145:592–603. doi: 10.1210/en.2003-1174. PubMed DOI

ALMEIDA S, RAPOSO A, GONZÁLES MA, CARRACOSSA C. Bisphenol A: food exposure and impact on human health. CRFSFS. 2018;17:1503–1517. doi: 10.1111/1541-4337.12388. PubMed DOI

ALWAAL A, BREYER BN, LUE TF. Normal male sexual function: emphasis on orgasm and ejaculation. Fertility and Sterility. 2015;104:1051–1060. doi: 10.1016/j.fertnstert.2015.08.033. PubMed DOI PMC

BRAUN JM. Early-life exposure to EDCs: role in childhood obesity and neurodevelopment. Nat Rev Endocrinol. 2017;13:161–173. doi: 10.1038/nrendo.2016.186. PubMed DOI PMC

BREMER AA, MILLER WL. Regulation of Steroidogenesis. In: Ulloa-Aguirre Alfredo, Michael Conn P., editors. Cellular Endocrinology in Health and Disease. Academic Press; 2014. pp. 207–227. DOI

CASTELLINI C, TOTARO M, PARISI A, D’ANDREA S, LUCENTE L, CORDESCHI G, FRANCAVILLA S, FRANCAVILLA F, BARDONETTI A. Bisphenol A nad male fertility: Myths and realities. Front Endocrinol. 2020;11:353–363. doi: 10.3389/fendo.2020.00353. PubMed DOI PMC

CASTELLINI C, DI GIAMMARCO N, D’ANDREA S, PARISI A, TOTARO M, FRANCAVILLA S, FRANCAVILLA F, BARBONETTI A. Effects of bisphenol S and bisphenol F on human spermatozoa: An in vitro study. Reproductive Toxicology. 2021;103:58–63. doi: 10.1016/j.reprotox.2021.05.011. PubMed DOI

CHEN D, KANNAN K, TAN H, ZHENG Z, FENG YL, WU Y, WIDELKA M. Bisphenol Analogues Other Than BPA: Environmental Occurrence, Human Exposure, and Toxicity-A Review. Environ Sci Technol. 2016;50:5438–53. doi: 10.1021/acs.est.5b05387. PubMed DOI

CHEN M, TANG R, FU G, ZHU P, QIAO S, CHEN X, XU B, QIN Y, LU C, HANG B, XIA Y, WANG X. Association of exposure to phenols and idiopathic male infertility. J Hazard Mat. 2013;250–251:115–121. https://doi.org/0.1016/j.jhazmat.2013.01.061 . PubMed

CIMMINO I, FIORY F, PERRUOLO G, MIELE C, BEGUINOT F, FORMISANO P, ORIENTE F. Potential mechanisms of Bisphenol A (BPA) contributing to human disease. Int J Molecular Sci. 2020;21:5761. doi: 10.3390/ijms21165761. PubMed DOI PMC

CLAVIJO RI, HSIAO W. Update on male reproductive endocrinology. Translational Andrology and Urology. 2018;7:367–372. doi: 10.21037/tau.2018.03.25. PubMed DOI PMC

CLEMENT P, GIULIANO F. Anatomy and physiology of genital organs - men. Handb Clin Neurol. 2015;130:19–37. doi: 10.1016/B978-0-444-63247-0.00003-1. PubMed DOI

COBELLIS L, COLACURCI N, TRABUCCO E, CARPENTIERO C, GRUMETTO L. Measurement of bisphenol A and bisphenol B levels in human blood sera from healthy and endometriotic women. Biomed Chromatogr. 2009;23:1186–90. doi: 10.1002/bmc.1241. PubMed DOI

CUNHA SC, ALMEIDA C, MENDES E, FERNANDES JO. Simultaneous determination of bisphenol A and bisphenol B in beverages and powdered infant formula by dispersive liquid-liquid micro-extraction and heart-cutting multidimensional gas chromatography-mass spectrometry. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2011;28:513–26. doi: 10.1080/19440049.2010.542551. PubMed DOI

CUNHA SC, CUNHA C, FERREIRA AR, FERNANDES JO. Determination of bisphenol A and bisphenol B in canned seafood combining QuEChERS extraction with dispersive liquid-liquid microextraction followed by gas chromatography-mass spectrometry. Anal Bioanal Chem. 2012;404:2453–63. doi: 10.1007/s00216-012-6389-5. PubMed DOI

CUNHA SC, FERNANDES JO. Quantification of free and total bisphenol A and bisphenol B in human urine by dispersive liquid-liquid microextraction (DLLME) and heart-cutting multidimensional gas chromatography-mass spectrometry (MD-GC/MS) Talanta. 2010;83:117–1250. https://doi.org10.1016/j.talanta.2010.08.048 . PubMed

DARBRE PD. Overview of air pollution and endocrine disorders. Int J Gen Med. 2018;11:191–207. doi: 10.2147/IJGM.S102230. PubMed DOI PMC

DEN HOND E, TOURNAYE H, DE SUTTER P, OMBELET Q, BAEYENS W, COVACI A, COX B, NAWROT TS, LAREBEKE NV, D’HOOGHE T. Human exposure to endocrine disrupting chmicals and fertility: a case-control study in male subfertility patients. Environ Inter. 2015;84:154–160. doi: 10.1016/j.envint.2015.07.017. PubMed DOI

DESDOITS-LETHIMONIER C, LESNÉ L, GAUDRIAULT P, ZALKO D, ANTIGNAC JP, DECEUNINCK Y, PLATEL C, DEJUCQ-RAINSFORD N, MAZAUD-GUITTOT S, JÉGOU B. Parallel assessment of the effects of bisphenol A and several of its analogs on the adult human testis. Hum Reprod. 2017;32:1465–1473. doi: 10.1093/humrep/dex093. PubMed DOI

DIAMANTI-KANDARAKIS E, BOURGUIGNON JP, GIUDICE LC, HAUSE R, PRINS GS, SOTO AM, ZOELLER T, GORE AC. Endocrine-disrupting chemicals: an endocrine society scientific statement. Endocr Rev. 2009;30:293–342. doi: 10.1210/er.2009-0002. PubMed DOI PMC

DONATO DM, CERNERA G, GIOVANNELI P, GALASSO G, BILANCIO A, MIGLIACCIO A, CASTORIA G. Recent advances on bisphenol-A and endocrine disruptor effects on human prostate cancer. Mol Cell Endoc. 2017;457:35–42. doi: 10.1016/j.mce.2017.02.045. PubMed DOI

ELADAK S, TIPHANY G, DLPHINE M, GUERQUIN MJ, N’THUMBA-BYN T, POZZI-GAUDIN S, BENACHI A, LIVERA G, ROUILLER-FABRE V, HABER R. A new chapter in the bisphenol A story: bisphenol S and bisphenol F are not safe alternatives to this compound. Fertil Steril. 2015;103:11–21. doi: 10.1016/j.fertnstert.2014.11.005. PubMed DOI

FATTORE M, RUSSO G, BARBATO F, GRUMETTO L, ALBRIZIO S. Monitoring of bisphenols in canned tuna from Italian markets. Food Chem Toxicol. 2015;83:68–75. doi: 10.1016/j.fct.2015.05.010. PubMed DOI

FIEGE H, VOGES HW, HAMAMOTO T, UMEMURA S, IWATA T, MIKI H, FUJITA Y, BUYSCH HJ, GARBE D, PAULUS W. Phenol derivatives. Ullmann’s Encyclopedia of Industrial Chemistry. 2000:643–647. doi: 10.1002/14356007.a19_313. DOI

GALLOWAY T, CIPELLI R, GURALNIK J, FERRUCCI L, BANDINELLI S, CORSI MA, MONEY C, McCORMACK P, MELZER D. Daily bisphenol A excretion and associations with sex hormone concentrations: results form the InCHIANTI adult population study. Environ Health Perspect. 2010;118:1603–1608. doi: 10.1289/ehp.1002367. PubMed DOI PMC

GHAYDA RA, WILLIAMS PL, CHAVARRO JE, FORD JB, SOUTER I, CALAFAT AM, HAUSER R, MÍNGUEZ-ALARCÓN L. Urinary bisphenol S concentrations: Potential predictors of and associations with semen quality parameters among men attending a fertility center. Environ Int. 2019;131:105050. doi: 10.1016/j.envint.2019.105050. PubMed DOI PMC

HEALTHDIRECT: Male reproductive system. 2021. https://www.healthdirect.gov.au/male-reproductive-system .

GOLDSTONE AE, CHEN Z, PERRY MJ, KANNAN K, LOUIS BMG. Urinary bisphenol A and semen quality, the LIFE study. Reprod Toxicol. 2015;51:7–13. doi: 10.1016/j.reprotox.2014.11.003. PubMed DOI PMC

GRUMETTO L, GENNARI O, MONTESANO D, FERRACANE R, RITIENI A, ALBRIZIO S, BARBATO F. Determination of five bisphenols in commercial milk samples by liquid chromatography coupled to fluorescence detection. J Food Prot. 2013;76:1590–1596. doi: 10.4315/0362-028X.JFP-13-054. PubMed DOI

HÉLIÈS-TOUSSAINT C, PEYRE L, COSTANZO C, CHAGNON MC, RAHMANI R. Is bisphenol S a safe substitute for bisphenol A in terms of metabolic function? An in vitro study. Toxicol Appl Pharmacol. 2014;280:224–235. doi: 10.1016/j.taap.2014.07.025. PubMed DOI

IBOR OR, ADEOGUN AO, REGOLI F, ARUKWE A. Xenobiotic biotransformation, oxidative stress and obesogenic molecular biomarker responses in Tilapia guineensis from Eleyele Lake, Nigeria. Ecotoxicol Environ Saf. 2019;169:255–265. doi: 10.1016/j.ecoenv.2018.11.021. PubMed DOI

ITTMANN M. Anatomy and Histology of the Human and Murine Prostate. Cold Spring Harbor Perspectives in Medicine. 2018;8:a030346. doi: 10.1101/cshperspect.a030346. PubMed DOI PMC

JAMBOR T, KOVACIKOVA E, GREIFOVA H, KOVACIK A, LIBOVA L, LUKAC N. Assessment of the effective impact of bisphenols on mitochondrial activity and steroidogenesis a dose-dependency in mice TM3 Leydig cells. Physiol Res. 2019;4:689–693. doi: 10.33549/physiolres.934200. PubMed DOI

KNEZ J, KRANVOGL R, BREZNIK BP, VONČINA E, VLAISAVLJEVIC V. Are urinary bisphenol A levels in men related to semen quality and embryo development after medically assisted reproduction? Fertil Steril. 2014;101:215–221. doi: 10.1016/j.fertnstert.2013.09.030. PubMed DOI

KRZASTEK SC, FARHI J, GRAY M, SMITH RP. Impact of environmental toxin exposure on male fertility potential. Translational Androl Urol. 2020;9:2797–2813. doi: 10.21037/tau-20-685. PubMed DOI PMC

LA MERRILL MA, VANDENBERG LN, SMITH MT, GOODSON W, BROWNE P, PATISAUL HB, GUYTON KZ, KORTENKAMP A, COGLIANO VJ, WOODRUFF TJ, RIESWIJK L, SONE H, KORACH KS, GORE AC, ZEIS L, ZOELLER RT. Consensus on the key characteristic of endocrine-disrupting chemicals as a basis for hazard identification. Nat Rev, Endocrinol. 2020;16:45–57. doi: 10.1038/s41574-019-0273-8. PubMed DOI PMC

LASSEN TH, FREDERIKSEN H, JENSEN TK, PETERSEN JH, JOENSEN UN, MAIN KM, SKAKKEBAEK NE, JUUL A, JORGENSEN N, ANDERSSON AM. Urinary bisphenol A levels in young men: association with reproductive hormones and semen quality. Environ Health Persp. 2014;122:478–484. doi: 10.1289/ehp.1307309. PubMed DOI PMC

LEHMLER HJ, LIU B, GADOGBE M, BAO W. Exposure to Bisphenol A, Bisphenol F, and Bisphenol S in U.S. Adults and children: the national health and nutrition examination survey 2013–2014. ACS Omega. 2018;3:6523–6532. doi: 10.1021/acsomega.8b00824. PubMed DOI PMC

LI DK, ZHOU Z, MIAO M, HE Y, WANG JT, FERBER J, HERRINTON LJ, GAO E, YUAN W. Urine bisphenol-A (BPA) level in relation to semen quality. Fertil Steril. 2011;95:625–630. doi: 10.1016/j.fertnstert.2010.09.026. PubMed DOI

LIAO C, KANNAN K. A survey of alkylphenols, bisphenols, and triclosan in personal care products from China and the United States. Arch Environ Contam Toxicol. 2014a;67:50–9. doi: 10.1007/s00244-014-0016-8. PubMed DOI

LIAO C, KANNAN K. A survey of bisphenol A and other bisphenol analogues in foodstuffs from nine cities in China. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2014b;31:319–329. doi: 10.1080/19440049.2013.868611. PubMed DOI

LIAO C, KANNAN K. Concentrations and profiles of bisphenol A and other bisphenol analogues in foodstuffs from the United States and their implications for human exposure. J Agric Food Chem. 2013;61:4655–4662. doi: 10.1021/jf400445n. PubMed DOI

LIAO C, LIU F, GUO Y, MOON HB, NAKATA H, WU Q, KANNAN K. Occurrence of eight bisphenol analogues in indoor dust from the United States and several Asian countries: implications for human exposure. Environ Sci Technol. 2012;46:9138–9145. doi: 10.1021/es302004w. PubMed DOI

LIU X, MIAO M, ZHOU Z, GAO E, CHEN J, WANG J, SUN F, YUAN W, LI DE. Exposure to bisphenol-A and reproductive hormones among male adults. Environ Toxicol Pharmacol. 2015;39:934–941. doi: 10.1016/j.etap.2015.03.007. PubMed DOI

LOTTI N, COLONNA M, FIORINI M, FINELLI L, BERTI C. Poly(butylene terephthalate) modified with ethoxylated bisphenol S with increased glass transition temperature and improved thermal stability. Polymer. 2011;52:904–911. doi: 10.1016/j.polymer.2011.01.018. DOI

LU S, YU Y, REN L, ZHANG X, LIU G, YU Y. Estimation of intake and uptake of bisphenols and triclosan from personal care products by dermal contact. Sci Total Environ. 2018;621:1389–1396. doi: 10.1016/j.scitotenv.2017.10.088. PubMed DOI

MEEKER JD, EHRLICH S, TOTH TL, WRIGHT DL, CALAFAT AM, TRISINI AT, YE X, HAUSER R. Semen quality and sperm DNA damage in relation to urinary bisphenol A among men form an infertility clinic. Repro Toxi. 2010;30:532–539. doi: 10.1016/j.reprotox.2010.07.005. PubMed DOI PMC

MEZZELANI M, GORBI S, REGOLI F. Pharmaceuticals in the aquatic environments: evidence of emerged threat and future challenges for marine organisms. Marine Environ Res. 2018;140:41–60. doi: 10.1016/j.marenvres.2018.05.001. PubMed DOI

NOSZCZYNSKA M, PIOTROWSKA-SEGET Z. Bisphenols: Application, occurrence, safety, and biodegradation mediated by bacterial communities in wastewater treatment plants and rivers. Chemosphere. 2018;201:214–223. doi: 10.1016/j.chemosphere.2018.02.179. PubMed DOI

PAOLI D, PALLOTTI F, DIMA AP, ALBANI E, ALVIGGI C, CAUSIO F, DIOGUARDI CC, CONFORTI A, CIRIMINNA R, FABOZZI G. Phthalates and bisphenol A: presence in blood serum and follicular fluid of Italian women undergoing assisted reproduction techniques. Toxics. 2020;8:1–15. doi: 10.3390/toxics8040091. PubMed DOI PMC

PARK HJ, LEE R, YOO H, HONG K, SONG H. Nonylphenol induces apoptosis through ROS/JNK signaling in a spermatogonia cell line. Int J Mol Sci. 2021;22:307–321. doi: 10.3390/ijms22010307. PubMed DOI PMC

PIVNENKO K, PEDERSEN GA, ERIKSSON E, ASTRUP TF. Bisphenol A and its structural analogues in household waste paper. Waste Manag. 2015;44:39–47. doi: 10.1016/j.wasman.2015.07.017. PubMed DOI

QIU W, SHAO H, LEI P, ZHEN CH, QIU C, YANG M, ZHENG Y. Immunotoxicity of bisphenol S and F are similar to that of bisphenol A during zebrafish early development. Chemosphere. 2018;194:1–8. doi: 10.1016/j.chemosphere.2017.11.125. PubMed DOI

RASHID H, ALQAHTANI SS, ALSHAHRANI S. Diet: a source of endocrine disruptors. Endoc Met Immu Dis. 2020;20:633–645. doi: 10.2174/1871530319666191022100141. PubMed DOI

RADWAN M, WIELGOMAS B, DZIEWIRSKA E, RADWAN P, KAŁUŻNY P, KLIMOWSKA A, HANKE W, JUREWICZ J. Urinary Bisphenol A Levels and Male Fertility. American Journal of Men’s Health. 2018;12:2144–2151. doi: 10.1177/1557988318799163. PubMed DOI PMC

RUSSO G, CAPUOZZO A, BARBATO F, IRACE C, SANTAMARIA R, GRUMETTO L. Cytotoxicity of seven bisphenol analogues compared to bisphenol A and relationships with membrane affinity data. Chemosphere. 2018;201:432–440. doi: 10.1016/j.chemosphere.2018.03.014. PubMed DOI

SABIR S, REHMAN K, FIAYYAZ F, KAMAL S, AKASH MSH. Role of aflatoxins as EDCs in metabolic disorders. In: AKASH MSH, REHMAN K, HASHMI MZ, editors. Endocrine Disrupting Chemicals - induced Metabolic Disorders and Treatment. Springer International Publishing; 2020. pp. 381–389. DOI

SAGHIR SA, ANSARI RA. Reference Module in Biomedical Sciences. 2019. Metabolism (Biotransfomation) in press. DOI

SALEM HM, Salam AA, SALAM AM, SELEIMAN MF. In: Soil xenobiotics and their phyto-chemical remediationXenobiotics in the Soil Environment. HASHIM M, KUMA V, VARMA A, editors. Springer International Publishing; 2017. pp. 267–280. DOI

SENGER P. 978-0965764803Pathways to Pregnancy and Parturition. 1997

SCINICARIELLO F, BUSER MC. Serum testosterone concentrations and urinary bisphenol A, benzophenone-3, triclosan and paraben levels in male and female children and adolescent: NHANES 2011–2012. Environ Health Perspect. 2016;124:1898–1904. doi: 10.1289/EHP150. PubMed DOI PMC

SHARMA A, MOLLIE J, BROCKLESBY RWK, CAVES CH, JAYASENA CHN, MINHAS S. Endocrine-disrupting chemicals and male reproductive health. Rep Med Biol. 2020;19:243–253. doi: 10.1002/rmb2.12326. PubMed DOI PMC

SIRACUSA JS, YIN L, MEASEL E, LINAG S, YU X. Effect of bisphenol A and its analogs on reproductive health: a mini review. Rep Toxi. 2018;79:96–123. doi: 10.1016/j.reprotox.2018.06.005. PubMed DOI PMC

SLAMA R, VERNET C, NASSAN FL, HAUSE R, PHILIPPAT C. Characterizing effect of endocrine disruptors on human health: the role of epidemiological cohorts. Comp Rend Biol. 2017;340:421–431. doi: 10.1016/j.crvi.2017.07.008. PubMed DOI

SUSSMAN EM, CHUDNOVSKY A, NIEDERBERGER CS. Hormonal Evaluation of the Infertile Male: Has It Evolved? Urologic Clinics of North America. 2008;35:147–155. doi: 10.1016/j.ucl.2008.01.010. PubMed DOI

TEEGUARDEN JG, CALAFAT AM, YE X, DOERGE DR, CHURCHWELL MI, GUNAWAN R, GRAHM MK. Twenty-four hour human urine and serum profiles of bisphenol A during high-dietary exposure. Toxicol Sci. 2011;123:48–57. doi: 10.1093/toxsci/kfr160. PubMed DOI

TOMZA-MARCINIAK A, STĘPKOWSKA P, KUBA J, PILARCZYK B. Effect of bisphenol A on reproductive processes: A review of in vitro, in vivo and epidemiological studies. J Applied Toxicol. 2018;38:51–80. doi: 10.1002/jat.3480. PubMed DOI

USMAN A, AHMAD M. From BPA to its analogues: Is it a safe journey? Chemosphere. 2016;158:131–42. doi: 10.1016/j.chemosphere.2016.05.070. PubMed DOI

VanDenBERG LN, HUNT PA, MYERS JP, VOM SAAL FS. Human exposures to bisphenol A: mismatches between data and assumptions. Rev Environ Health. 2013;28:37–58. doi: 10.1515/reveh-2012-0034. PubMed DOI

VOLKEL W, COLNOT T, CSANÁDY GA, FILSER JG, DEKANT W. metabolism and kinetics of bisphenol A in humans at low doses following oral administration. Chem Res Toxicol. 2002;15:1281–1287. doi: 10.1021/tx025548t. PubMed DOI

VOM SAAL SF, VANDENBERG LN. Update on the health effects of bisphenol A: overwhelming evidence of harm. Endocrinology. 2020;162:171. doi: 10.1210/endocr/bqaa171. PubMed DOI PMC

WANG H, LIU ZH, TANG Z, ZHANG J, YIN H, DANG Z, WU PX, LIU Y. Bisphenol analogues in Chinese bottled water: Quantification and potential risk analysis. Sci Total Environ. 2020;713:136583. doi: 10.1016/j.scitotenv.2020.136583. PubMed DOI

WAZIR U, MOKBEL K. Bisphenol A: a concise review of literature and discussion of health and regulatory implications. In vivo. 2019;33:1421–1423. doi: 10.21873/invivo.11619. PubMed DOI PMC

WU H, WU LH, WANG F, GAO CHJ, CHEN D, GUO Y. Several environmental endocrine disruptors in beverages from south China: occurrence and human exposure. Environ Sci Poll Res. 2019;26:5873–5884. doi: 10.1007/s11356-018-3933-7. PubMed DOI

YE X, WONG LY, KRAMER J, ZHOU X, JIA T, CALAFAT AM. Urinary Concentrations of Bisphenol A and Three Other Bisphenols in Convenience Samples of U.S. Adults during 2000–2014. Environ Sci Technol. 2015;49:11834–9. doi: 10.1021/acs.est.5b02135. PubMed DOI PMC

YILMAZ B, TEREKECI H, SANDAL S, KELESTIMUR F. Endocrine disrupting chemicals: exposure, effects on human health, mechanism of action, models for testing and strategies for prevention. Rev Endocr Metab Disord. 2020;21:127–147. doi: 10.1007/s11154-019-09521-z. PubMed DOI

ZHANG YF, SHAN CH, WANG Y, QIAN LL, JIA DD, ZHANG YF, HAO XD, XU HM. Cardiovascular toxixity and mechanism of bisphenol A and emerging risk of bisphenol S. Sci Tot Environ. 2020;723:137952. doi: 10.1016/j.scitotenv.2020.137952. PubMed DOI

ZHOU X, KRAMER JP, CALAFAT AM, YE X. Automated on-line column-switching high performance liquid chromatography isotope dilution tandem mass spectrometry method for the quantification of bisphenol A, bisphenol F, bisphenol S, and 11 other phenols in urine. J Chromatogr B Analyt Technol Biomed Life Sci. 2014;944:152–156. doi: 10.1016/j.jchromb.2013.11.009. PubMed DOI

Toxicity of bisphenol A and its replacements in the mice Leydig cells in vitro